Description
Latin name
ETOPOSIDE-LANS
Release form
Concentrate for solution for infusion.
Packaging
In a bottle of 5 ml of concentrate. In a cardboard box 1 bottle.
Indications
Germ cell tumors (tumors of the testis, choriocarcinoma)
ovarian cancer
small cell and non-small cell lung cancer
Hodgkin
non-Hodgkin’s lymphoma
gastric cancer (for monotherapy and in combination therapy)
Ewing’s sarcoma
Kaposi’s sarcoma
neuroblastoma
breast cancer (with metastases to the liver, pleura)
acute non-lymphoblastic leukemia
mesothelioma.
Contraindications
Severe myelodepression
severe dysfunction of the liver and kidneys
pregnancy
children under 2 years of age
hypersensitivity to podophyllus or its derivatives.
Use during pregnancy and lactation
Etoposide is contraindicated in pregnancy. If necessary, use during lactation should stop breastfeeding.
During treatment and within 3 months after its completion, patients of childbearing age must use effective methods of contraception.
In experimental studies, etoposide has a teratogenic and embryotoxic effect.
Composition
1 ml (1 vial) contains:
Active substances: etoposide 20 mg (100 mg).
Dosage and administration of
I / O for 30 60 min (previously diluted with 0.9% sodium chloride solution or 5% glucose solution to a final concentration of 0.2 0.4 mg / ml) – 50 100 mg / m2 / day for 4 5 days, every 3-4 weeks or 100 125 mg / m2 on days 1, 3, 5. The drug is mainly used in combination with other chemotherapeutic agents. Repeated courses are carried out only after normalization of peripheral blood counts.
Side effects
From the hematopoietic system: leukopenia, anemia less often – thrombocytopenia.
From the digestive system: nausea, vomiting rarely – anorexia, mucositis, diarrhea when used in high doses – toxic reactions from the liver.
From the side of the central nervous system and peripheral nervous system: drowsiness, fatigue damage to the peripheral nervous system.
From the side of metabolism: hyperuricemia with high doses – metabolic acidosis.
From the cardiovascular system: tachycardia, arterial hypotension.
From the reproductive system: azoospermia, amenorrhea.
Allergic reactions: chills, fever, bronchospasm.
Dermatological reactions: alopecia.
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Storage conditions
Store at 15-30 ° C.
Shelf life
3 years.
Deystvuyushtee substance
topozid
Terms and conditions
prescription
