Description
Pharmacological action of
Essential phospholipids are the main elements of the structure of the cell wall and liver cell organelles. In liver diseases, there is always damage to the membranes of the liver cells and their organelles, which leads to impaired activity of the associated enzymes and receptor systems, impaired functional activity of the liver cells and reduced ability to regenerate.
Phospholipids,
Esslial forte, which is part of the drug, is chemically consistent with endogenous phospholipids, but surpasses endogenous phospholipids in activity due to their higher content of polyunsaturated (essential) fatty acids.
The incorporation of these high-energy molecules into the damaged sections of the hepatocyte cell membranes restores the integrity of the liver cells and promotes their regeneration.
Cis double bonds of their polyunsaturated fatty acids prevent the parallel arrangement of hydrocarbon chains in the cell wall phospholipids, the density of the phospholipid structure of the cell wall of hepatocytes decreases, which increases their fluidity and elasticity, improves metabolism.
The resulting functional blocks increase the activity of enzymes fixed on the membranes and contribute to the normal physiological pathway of the most important metabolic processes.
The phospholipids that are part of
Esslial forte regulate lipoprotein metabolism by transferring neutral fats and cholesterol to oxidation sites, mainly due to an increase in the ability of high density lipoproteins to bind to cholesterol.
Thus, there is a normalizing effect on the metabolism of lipids and proteins on the detoxification function of the liver and phospholipid-dependent enzyme systems, which ultimately prevents the formation of connective tissue in the liver and promotes the natural restoration of liver cells.
When phospholipids are excreted into bile, the lithogenic index decreases and bile stabilizes
Indications
Chronic hepatitis,
liver cirrhosis,
fatty liver of various etiologies,
toxic liver damage,
alcoholic hepatitis,
liver dysfunction in other somatic diseases.
Toxicosis of pregnancy,
prevention of recurrence of gallstone formation,
psoriasis (as an adjuvant),
radiation syndrome.
Contraindications
Individual intolerance to phosphatidylcholine or other auxiliary components of the drug.
Soy intolerance.
Children under 12 years of age (lack of sufficient evidence).
Composition
1 capsule contains:
Active ingredient:
lipoid PPL-400 – 400.0 mg, in terms of polyunsaturated phospholipids from soya lecithin (PPL fraction) – 300.0 mg, with an average content of L – phosphatidylchol % – 228.0 mg.
Excipients:
ethyl alcohol 95% – 4.0 mg.
Hard gelatine capsules No. 0:
Capsule body composition: iron oxide black – 0.01%, iron oxide red – 0.01%, yellow iron oxide dye – 0.1714%, titanium dioxide – 3%, gelatin – up to 100%
Capsule cover composition: black iron oxide dye – 0.53%, red iron oxide dye – 0.93%, yellow iron dye – 0.2%, titanium dioxide – 0.3333%, gelatin – up to 100%
Dosage and Administration
Inside. Capsules should be taken whole, washed down with a sufficient amount of water (approximately 1 cup).
For adolescents over 12 years old and weighing more than 43 kg, as well as for adults, Esslial forte is recommended to take 2 capsules – 3 times a day with meals.
As a rule, the duration of use is unlimited.
Side effects
Essial forte is usually well tolerated by patients.
In order to assess the incidence of side effects, the following definitions are used:
very often (> 1/10), often (> 1/100 – <1/10), not often (> 1/1000 – <1/100), rarely (> 1/10000 – <1/1000), very rarely (<1/10000), unknown frequency (it is impossible to determine the frequency of occurrence according to available data). From the gastrointestinal tract: rarely – discomfort in the epigastric region, loose stools, nausea, gastralgia. Allergic reactions: very rarely – rash, exanthema, urticaria, unknown frequency – itching. Storage conditions In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children. Expiration 3 years. Do not use after the expiration date indicated on the package. active substance Multivitamins, Phospholipids of pharmacies tempering conditions without prescription dosage form capsules
