Description
Pharmacological action
Antifungal agent of the allylamine group. It has an effect due to the suppression of squalene epoxidase in the cell membrane of the fungus. This leads to a deficiency of ergosterol and to intracellular accumulation of squalene, which causes the death of the pathogen cell.
Has a fungicidal effect on dermatophytes, molds and some dimorphic fungi, yeast and yeast-like fungi. It can act fungistatically on some types of yeast.
Active against pathogens of dermatomycosis (Trichophyton / including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum /, also Microsporum canis and Epidermophyton floccosum) of yeast-like fungi of the genus Candida (mainly Candida albicans) of the causative agent of colorful lichen (Malassezia furfur).
Indications
For oral administration: fungal skin lesions caused by dermatophytes – trichophytosis, epidermophytosis, microsporia, fungal infections of the nails (onychomycosis), candidiasis.
For external use: fungal skin lesions caused by dermatophytes, candidiasis versicolor versicolor.
Contraindications
Hypersensitivity to terbinafine.
Special instructions
Caution is advised to use terbinafine for oral administration in patients with impaired liver and / or kidney function, as well as in the elderly.
Composition
1 tab. contains:
Active substances:
terbinafine hydrochloride – 281 mg, which corresponds to the content of terbinafine – 250 mg.
Excipients:
lactose monohydrate (milk sugar) – 102.8 mg,
sodium carboxymethyl starch (type A) – 25.8 mg,
hypromellose – 12.9 mg,
silicon dioxide colloidal – 3.2 mg,
4.3 mg magnesium stearate.
Dosage and administration of
Inside adults – 250 mg / day in 1 or 2 doses.
The duration of treatment depends on the indications and severity of the infection: for skin lesions – 2-4 weeks., for nail damage – from 6 weeks. up to 4 months or more. For children weighing more than 40 kg – 250 mg / day, 20-40 kg – 125 mg / day, up to 20 kg – 62.5 mg / day.
Topically applied 1-2 times / day for 1-2 weeks.
Side effects of the digestive system: nausea, anorexia, moderate abdominal pain, diarrhea, disturbances or loss of taste, cholestasis, jaundice, hepatitis.
Allergic reactions: skin rash rarely – arthralgia, myalgia, erythema multiforme, Stevens-Johnson syndrome.
From the side of the central nervous system: headache.
From the hemopoietic system: neutropenia, thrombocytopenia.
Local reactions: hyperemia, itching, burning sensation.
active substance
Terbinafine
Terms of delivery from
pharmacies Prescription
Dosage form
tablets
