Description
Pharmacological action
Pharmacodynamics
Antimicrobial agent, derivative of nitrofuran. Bacterial flavoproteins, restoring the 5-nitro group, form highly reactive amino derivatives that can cause conformational changes in proteins (including ribosomal) and other macromolecules, leading to the death of bacteria. Active against gram-positive and gram-negative bacteria (including Staphylococcus spp., Streptococcus spp., Escherichia coli, Clostridium perfringens). Sustainability develops slowly and does not reach a high degree.
Pharmacokinetics
With external and local application, absorption is negligible. Penetrates through histohematological barriers and is evenly distributed in fluids and tissues. The main pathway of metabolism is restoration of the nitro group. It is excreted by the kidneys and partially with bile.
Indications
Outwardly: purulent wounds, pressure sores, burns of the II-III degree, minor skin lesions (including abrasions, scratches, cracks, cuts).
Locally: blepharitis, conjunctivitis, osteomyelitis, empyema of the paranasal sinuses and pleura of a urinary tract infection – flushing cavities, acute tonsillitis, stomatitis, gingivitis.
If necessary, please consult your doctor before using the medicine.
Contraindications
Hypersensitivity to nitrofural, nitrofuran derivatives and / or other components of the drug, bleeding, allergic dermatoses, severe renal dysfunction.
Composition
Composition per tablet
Active ingredient:
Nitrofural (furatsilin) - 20 mg
Excipient:
sodium chloride – 800 mg
Dosage and administration
Locally, externally in the form of a 0.02% freshly prepared aqueous solution: immediately before use, one tablet (20 mg of furatsilin) ​​is dissolved in 100 ml of distilled or warm boiled water.
Hot water is recommended for faster dissolution. Then the solution is cooled to room temperature.
Outwardly: in the form of an aqueous 0.02% solution – irrigate wounds, apply wet dressings.
Locally: blepharitis, conjunctivitis – instillation of an aqueous 0.02% solution into the conjunctival sac.
Osteomyelitis after surgery – rinsing the cavity followed by a wet dressing.
Side effects
Allergic reactions, dermatitis, skin itching are possible.
If any of the side effects indicated in the instructions are aggravated, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.
Drug Interactions
Not studied.
Dosage form
soluble tablets
Prescribing
For pregnant women prescribed by a doctor, For children prescribed by a doctor, For adults, Nursing mothers
Indications
Conjunctivitis, Minor skin lesions, From sore throat, From tonsillitis, Burns, From inflammation of the gums, From bedsores, Infectious wounds, From stomatitis, From infections eyes, blepharitis
