Description
Pharmacological action
Nootropic agent. Citicoline, being the precursor of key ultrastructural components of the cell membrane (mainly phospholipids), has a wide spectrum of action: it helps to restore damaged cell membranes, inhibits the action of phospholipases, preventing the excessive formation of free radicals, and also prevents cell death by acting on the mechanisms of apoptosis.
In the acute period of a stroke, reduces the volume of damaged tissue, improves cholinergic transmission.
In traumatic brain injury, it reduces the duration of post-traumatic coma and the severity of neurological symptoms.
Citicoline improves symptoms observed during hypoxia: memory impairment, emotional lability, lack of initiative, difficulties in performing daily activities and self-care.
Effective in the treatment of cognitive, sensitive and motor neurological disorders of degenerative and vascular etiology.
Indications
Ischemic stroke (acute period) ischemic and hemorrhagic stroke (recovery period) traumatic brain injury (acute and recovery period) cognitive impairment in degenerative and vascular diseases of the brain.
Contraindications
Vagotonia (predominance of the tone of the parasympathetic part of the autonomic nervous system) children and adolescents under 18 years of age are hypersensitive to citicoline.
Recommendations for use
When taken orally – 200-300 mg 3 times / day.
IV in strokes and traumatic brain injury in the acute period – 1-2 g / day, depending on the severity of the disease for 3-7 days, followed by a transition to the / m introduction or ingestion.
V / m – 0.5-1 g / day.
Special instructions
Citicoline should not be used concurrently with medicines containing meclofenoxate.
Composition
The oral solution is colorless, yellowish or tan, clear.
1 ml
sodium citicoline 104.5 mg,
corresponding to citicoline 100 mg
Excipients:
sorbitol liquid non-crystallizing – 200 mg,
anhydrous glycerol – 50 mg,
sodium citrate (sodium citrate acid 6 mg, citrate anhydrous – up to pH 5.0-7.0,
water d / and up to 1 ml.
Side effects of
From the central nervous system and peripheral nervous system: insomnia, headache, dizziness, agitation, tremor, numbness in paralyzed limbs.
From the digestive system: nausea, decreased appetite, changes in the activity of liver enzymes.
Allergic reactions: rash, itching of the skin, anaphylactic shock.
Other: fever in some cases – short-term hypotensive effect, stimulation of the parasympathetic nervous system.
active substance
Citicoline
Conditions of supply of
pharmacies Prescription
dosage rma
injection
