Description
Pharmacological action
Mechanism of action
Natamycin is a macrolide antifungal antibiotic with a wide spectrum of action. It has a fungicidal effect. It binds to sterols of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms.
Active against most pathogenic yeast-like fungi (especially Candida albicans), yeast (Torulopsis and Rhodotorula), as well as other pathogenic fungi (Aspergillus, Penicillium). Less active against dermatophytes (Trichophyton, Microsporum, Epidermophyton).
In vitro sensitivity
He affects in vitro gram-positive and gram-negative bacteria.
Resistance
Natamycin resistance is not found in clinical practice.
Pharmacokinetics
Natamycin does not have a systemic effect, because practically not absorbed through intact skin and intact mucous membranes.
Indications
Vaginitis, vulvitis, vulvovaginitis caused by fungi of the genus Candida.
Contraindications
Hypersensitivity to the components of the drug.
Ingredients
1 supp.
natamycin (in terms of 100% substance) 100 mg
Excipients: macrogol glyceryl hydroxystearate – 75 mg, colloidal silicon dioxide – 20 mg, solid fat (Suppocir AM) – up to 1500 mg.
Dosage and administration
Dosage and administration: for vaginal use.
Suppositories, previously freed from the contour packaging, are injected into the vagina, while in the supine position, as deep as possible 1 time / day at night.
Dosing
For candida vaginitis, vulvitis. vulvovaginitis: intravaginally one suppository for 3-6 days.
The duration of treatment is set individually. After the symptoms disappear, it is recommended to continue treatment for a few more days. For the period of menstruation, the use of suppositories is interrupted.
With the persistent course of vaginitis caused by Candida albicans, natamycin is additionally prescribed in the form of tablets for oral administration: 1 tablet 4 times / day for 10-20 days to sanitize the focus of candidal infection in the intestines.
Side effects
When applied topically, slight irritation and a burning sensation at the injection site are possible.
Drug interaction
Drug interaction of the drug Natamycin with other drugs is not described.
Storage conditions
The drug should be stored in a place protected from moisture and light, out of the reach of children, at a temperature not exceeding 25 ° C.
Do not use after the expiration date printed on the package.
Shelf life
2 years.
Active ingredient
natamycin
pharmacy terms with a prescription
lekarstvennaja form
suppozytoryy vahynaln e
