Description
Pharmacological action
The combination of hesperidin + diosmin has venotonic and angioprotective properties. Reduces the extensibility of veins and venous congestion, in microcirculation – reduces the permeability of capillaries and increases their resistance, improves venous hemodynamics. It affects the following venous plethysmographic parameters: venous capacity, venous extensibility, time of venous emptying.
The optimal effect is achieved with 1000 mg. The combination of hesperidin + diosmin increases venous tone by reducing the time of venous emptying. In patients with signs of severe microcirculatory disorders, an increase in capillary resistance is noted.
The combination of hesperidin + diosmin is effective in the treatment of chronic lower limb vein diseases, as well as in the treatment of hemorrhoids.
Pharmacokinetics
The drug Detravenol is primarily excreted through the intestines. The kidneys, on average, remove about 14% of the dose taken.
The elimination half-life is 11 hours.
The drug undergoes an active metabolism, which is confirmed by the presence of phenolic acids in the urine.
Indications
Therapy for symptoms of chronic venous disease (elimination and relief of symptoms).
Therapy for symptoms of venous-lymphatic insufficiency:
pain
cramps of the lower extremities
feeling of heaviness and fullness in the legs
“tired” legs.
Therapy for manifestations of venous-lymphatic insufficiency: edema of the lower extremities
trophic changes in the skin and subcutaneous tissue
venous trophic ulcers.
Symptomatic therapy of acute and chronic hemorrhoids.
Contraindications
Hypersensitivity to the components of the drug
Period of breastfeeding (limited experience).
Special instructions
Before you start taking the drug Detravenol, it is recommended to consult a doctor.
With exacerbation of hemorrhoids, the administration of the drug Detravenol does not replace the specific treatment of other anal disorders.
The duration of treatment should not exceed the time specified in the section “Dosage and administration”. In the event that the symptoms do not disappear after the recommended course of therapy, an examination by a proctologist should be performed, who will select further therapy.
In the presence of impaired venous circulation, the maximum treatment effect is ensured by a combination of therapy with a healthy (balanced) lifestyle, it is advisable to avoid long exposure to the sun, prolonged stay on the legs, and it is recommended to reduce excess body weight. Hiking and. in some cases, wearing special stockings improves blood circulation.
If there is no decrease or if symptoms of the disease worsen, consult a doctor!
Do not exceed the maximum dates and recommended doses of the drug without consulting your doctor!
Effect on the ability to drive vehicles and mechanisms
The drug does not affect the ability to drive vehicles and mechanisms.
Composition
Nna 1 tablet:
active substance: purified micronized flavonoid fraction, including: diosmin (90%) – 450,000 mg of flavonoids in terms of hesperidin (10%) – 50,000 mg.
excipients (core): gelatin – 13,500 mg, sodium carboxymethyl starch – 27,000 mg, magnesium stearate – 6,500 mg, microcrystalline cellulose – up to 650,000 mg.
sheath composition: Opadry II 85F240012 Pink – 20,000 mg: polyvinyl alcohol – 8.000 mg, macrogol-3350 – 4.876 mg, iron dye red oxide – 0.080 mg, yellow iron dye oxide – 0.044 mg, talc – 2.960 mg, titanium dioxide – 4.040 mg.
Dosage and Administration
Inside.
The recommended dose for venous-lymphatic insufficiency is 2 tablets per day, preferably in the morning, during meals.
The duration of treatment can be several months (up to 12 months). In case of recurrence of symptoms, on the recommendation of a doctor, the course of treatment can be repeated.
The recommended dose for acute hemorrhoids is 6 tablets per day (3 tablets in the morning and 3 tablets in the evening) for 4 days, then 4 tablets per day (2 tablets in the morning and evening) for the next 3 days.
The recommended dose for chronic hemorrhoids is 2 tablets per day.
Side effects
The frequency of side effects is determined according to the WHO classification of adverse drug reactions according to the frequency of occurrence, very often more than 1/10, often more than 1/100 and less than 1/10, infrequently more than 1/1000 and less than 1/100 , rarely – more than 1/10000 and less than 1/1000, very rarely – less than 1/10000, including isolated cases of unknown frequency (it is impossible to determine the frequency of occurrence of an undesirable reaction from the available data).
From the central nervous system: rarely – headache, dizziness, general malaise.
From the gastrointestinal tract: often – diarrhea, dyspepsia, nausea, vomiting infrequently – colitis of unspecified frequency – abdominal pain.
From the skin and subcutaneous fat: rarely – skin rash, itching, urticaria of unspecified frequency – isolated swelling of the face, lips, eyelids in exceptional cases – angioedema.
If you have any side effects that are indicated in the instructions, or they are exacerbated, or you notice any other side effects that are not listed in the instructions, inform your doctor.
Storage conditions
At a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Shelf life
3 years. Do not use after expiration date.
active substance
Purified micronized flavonoid fraction (diosmin, flavonoids based on hesperidin)
Terms of delivery from pharmacies
Over-the-counter
tablet form
