Description
Pharmacological action
Semi-synthetic bioflavonoid (a rutin derivative) of the benzopyran class, has P-vitamin activity, has venotonic, angioprotective, anti-inflammatory and anti-edematous effects, reduces capillary permeability and fragility. Its pharmacodynamic properties are associated with the participation of troxerutin bioflavonoids in redox processes and inhibition of hyaluronidase. By inhibiting hyaluronidase, troxerutin stabilizes the hyaluronic acid of the cell membranes and reduces their permeability.
It has antioxidant activity, as a result of which it prevents the oxidation of ascorbic acid, adrenaline and lipids. In addition, it reduces the permeability and fragility of capillaries, prevents damage to the basement membrane of endothelial cells when exposed to various factors. Troxerutin increases the density of the vascular wall, reduces the exudation of the liquid part of the plasma and the diapedesis of blood cells.
Reduces exudative inflammation in the vascular wall, reducing platelet adhesion to its surface.
Inhibits aggregation and increases the degree of red blood cell deformation. The use of troxerutin is possible, both in the initial and late stages of treatment of chronic venous insufficiency, it is possible to use as one of the components of complex treatment. Troxerutin reduces swelling and a feeling of heaviness in the legs, reduces the intensity of pain and cramps, improves trophic tissue. Troxerutin alleviates the symptoms associated with hemorrhoids (pain, exudation, itching, bleeding). Due to its effect on the permeability and resistance of capillary walls, troxerutin helps to slow the progression of diabetic retinopathy.
The effect of troxerutin on the rheological properties of blood helps prevent the development of retinal vascular microthrombosis.
Indications
The drug Phlebopress® 300 mg capsules is used as part of the complex therapy of these diseases:
• chronic venous insufficiency
• trophic disorders in chronic venous insufficiency and trophic ulcers
• varicose veins
• superficial thrombophlebitis, peripheral
syndrome • post-thrombotic syndrome
• post-traumatic pulmonary edema and hematoma tissue and hematoma removal of varicose veins of the lower extremities
• hemorrhoids (to alleviate symptoms)
• diabetic angiopathy, retinopathy.
Contraindications
• Hypersensitivity to troxerutin and other components of the
preparation • Peptic ulcer, duodenal ulcer, chronic gastritis in the acute phase
• Lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome
• Pregnancy (I trimester)
• Breastfeeding period
• Children under 18 years of age (limited experience)
Composition
Composition per 1 capsule: active substance: troxerutin – 300.00 mg
Dosage and Administration
Inside. Capsules should be swallowed whole during meals, with plenty of water. At the initial stage of treatment, 1 capsule (300 mg) is prescribed 3 times a day. The effect usually develops within 2 weeks. Further, treatment is continued at the same dose or reduced to the average therapeutic dose – 1 capsule 2 times a day (600 mg), or suspended (while the effect achieved remains for at least 4 weeks).
If necessary, the dose can be increased after consulting a doctor. The course of treatment averages 3-4 weeks. For maintenance therapy, taking 1 capsule (300 mg) per day for 3-4 weeks is sufficient. In diabetic retinopathy, PhlebopressВ® is prescribed in 2 capsules (single dose of 600 mg) 3 times a day (daily dose of 1.8 g). On average, the duration of a therapeutic course is 3-4 weeks. The need for a longer treatment is determined after consultation with a doctor and individually.
Active substance
Troxerutin
Terms of delivery from
pharmacies Over-the-counter
