Description
Latin name
Clotrimazole
release form
vaginal tablets
Packing
6 pcs
Pharmacological action
Clotrimazole – trichomonacid, antiprotozoal, antifungal, antibacterial.
Destroys the cytoplasmic membrane of microorganisms with the formation of vacuoles inside the cell, inhibits the synthesis of nucleic acids and proteins.
Pharmacodynamics
It has a wide range of fungicidal effects: effective against yeast (Candida albicans) and mold (phycomycetes) fungi, dermatophytes (including Trichophyton, Epidermophyton, Microsporum), Malassezia furfur includes an antibacterial spectrum. h Corynebacterium minutissima.
Pharmacokinetics
Poorly absorbed from the skin and mucous membranes. Accumulates in the stratum corneum of the epidermis.
Indications
Vulvovaginal candidiasis, Trichomonas vaginitis, with a preventive purpose before gynecological procedures.
Contraindications
Hypersensitivity to clotrimazole, I trimester of pregnancy.
Use during pregnancy and lactation
In clinical and experimental studies, it was not found that the use of clotrimazole during pregnancy and lactation has a negative effect on the health of a woman or fetus (child).
However, the question of the advisability of prescribing clotrimazole should be decided individually after consulting a doctor.
In case of prescribing the drug to a pregnant woman, she should be warned that the applicator should not be used with the introduction of vaginal tablets.
Composition
1 tablet contains:
Active ingredient:
clotrimazole 100 mg
Excipients:
lactose,
corn starch,
aerosil,
saric acid,
soda acid
Dosage and administration
Deep in the vagina, in the supine position, with slightly bent legs – 1 tablet 100 mg once a day (in the evening) for 6 days. A second course of treatment is possible after consulting a doctor.
For the rehabilitation of the birth canal, a single administration of one tablet is recommended.
Side effects
Lower gastrointestinal spasms, generalized erythema, rash, local allergic reactions (burning, itching).
Drug Interaction
Reduces the effects of polyene antibiotics (amphotericin, nystatin, natamycin, etc.).
Para-hydroxybenzoic acid propyl ester in high concentrations enhances the antifungal action of clotrimazole, dexamethasone decreases.
Clotrimazole activity may be decreased when co-administered with nystatin.
Storage Conditions
In a dry, dark place at 15 25 ° C.
Shelf life
3 years
Deystvuyushtee substance
Clotrimazole
dosage form
vaginal tablets
Appointment
Appointment
Pregnant women II and III trimester as prescribed by the doctor, Adults, Nursing mothers, For women
GlaxoSmithKline, UK
