Description
Latin name
Chymotrypsin
Packing
10 vials.
Pharmacological action
Chymotrypsin is a proteolytic enzyme preparation obtained from the pancreas of cattle.
Hydrolyzes proteins and peptones to form relatively low molecular weight peptides, breaks down bonds formed by aromatic amino acid residues (tyrosine, tryptophan, phenylalanine, methionine).
In medical practice, the use of chymotrypsin is based on a specific feature of cleaving necrotic tissues and fibrinous formations, thinning viscous secrets and exudates, and, when administered intramuscularly, have an anti-inflammatory effect.
Indications
Suppurative respiratory diseases: tracheitis, bronchitis, bronchiectasis, pneumonia, lung abscesses, atelectasis, exudative pleurisy, bronchial asthma.
In the treatment of burns, bedsores, purulent wounds, thrombophlebitis.
In ophthalmology: with fresh extensive thrombosis of the central retinal vein, acute obstruction of the central retinal artery, opacification of the vitreous body of traumatic and inflammatory origin, cataract extraction.
In otolaryngology: with purulent sinusitis, subacute laryngotracheitis, after tracheostomy to facilitate the removal of thick viscous exudate, with acute, subacute, purulent, chronic otitis media and eustachitis with viscous exudate.
Contraindications
Hypersensitivity to chymotrypsin.
Malignant neoplasms.
Pulmonary tuberculosis (open form).
Chronic heart failure II – III degree.
Dystrophy and cirrhosis of the liver.
Viral hepatitis.
Pancreatitis.
Hemorrhagic diathesis.
Pulmonary emphysema with respiratory failure.
Do not inject into bleeding cavities, apply to ulcerated surfaces of malignant tumors in order to prevent the spread of the malignant process.
Use with caution in empyema of the pleura of tuberculous ethnology (resorption of exudate may in some cases contribute to the development of bronchopleural fistula).
Special instructions
Do not inject into bleeding cavities, apply to ulcerated surfaces of malignant tumors.
Dosage and administration
For intramuscular administration, immediately before use, 0.005 g of the drug in 1-2 ml of sterile 0, 9% sodium chloride solution or 0.5-2% procaine solution.
The course of treatment is 6-15 injections.
For respiratory diseases: the drug is administered intramuscularly in doses of 5-10 mg per day for 10-12 days, a combination with the use of chymotrypsin aerosol in a 5% aqueous solution in an amount of 3-4 ml is possible. After 7-10 days, the course of treatment can be repeated.
In the treatment of burns and pressure sores: Chymotrypsin at a dose of 20 mg is dissolved in 20 ml of a 0.25% procaine solution and injected under a scab with a small needle.
In the treatment of purulent wounds: on purulent wound surfaces apply sterile wipes moistened with a solution of 0.025-0.05 g of chymotrypsin in 10-50 ml of a 025% procaine solution for 8 hours. For the treatment of purulent wounds, intramuscular injections of the drug are combined with local treatment of wounds with tampons, moistened with a 5% aqueous solution of chymotrypsin.
With thrombophlebitis: the drug is administered intramuscularly at 5-10 mg daily for 7-10 days.
During cataract extraction: 1: 5000 chymotrypsin is introduced into the posterior chamber of the eye, followed by washing of the anterior chamber of the eye with 0.9% sodium chloride solution 4 minutes after drug administration.
In the treatment of central retinal vein thrombosis, acute obstruction of the central retinal artery: Chymotrypsin is administered subconjunctively in 0.2 ml of a 5% solution prepared in a 1% procaine solution, 1-2 times a week.
For sinusitis: the drug is injected into the appropriate cavity in an amount of 5-10 mg in 3-5 ml of 0.9% sodium chloride solution after puncture and rinsing of the cavity.
For otitis media: instill 0.5-1 ml of 0.1% chymotrypsin solution in 0 in the ear, 9% sodium chloride solution.
During microoperations on the ear to soften fibrinous formations in the middle ear: during surgery, a 0.1% chymotrypsin solution is injected into the cavity. At the same time, chymotrypsin should be administered intramuscularly 2.5-5 mg 1-2 times a day.
The drug is diluted in 1-2 ml of 0.25-0.5% solution of novocaine or 0.9% sodium chloride solution.
Side effects
Possibly: an allergic reaction.
Storage conditions
In the dark place at a temperature of no higher than 20 ° C.
Term hodnosty
3 years
Active ingredient
Chymotrypsin
dosage form
solution for injection
Samson -Med OJSC, Russia
