Description
release form s rdlkp film-coated tablets
Packing
30 tablets.
Pharmacological action
Antipsychotic agent (antipsychotic), a derivative of thioxanthene. It has antipsychotic, antidepressant, sedative, antiemetic effect, has alpha-adrenergic blocking activity.
It is believed that antipsychotic effects are associated with blockade of postsynaptic dopamine receptors in the brain. Antiemetic effect is associated with blockade of the chemoreceptor trigger zone of the medulla oblongata. Sedation is due to indirect weakening of the activity of the reticular system of the brain stem. Suppresses the release of most hormones of the hypothalamus and pituitary gland. However, as a result of the blockade of the prolactin-inhibiting factor that inhibits the release of prolactin from the pituitary gland, the prolactin concentration rises.
In terms of chemical structure and pharmacological properties, thioxanthenes are similar to piperazine derivatives of phenothiazine.
Indications
Chlorprotixen is a sedative antipsychotic with a wide range of indications, which include:
psychoses, including schizophrenia and manic states, which occur with psychomotor agitation, agitation and anxiety,
, alcohol addiction, and alcohol withdrawal symptoms confusion in elderly patients
impaired behavior in children
depressive states, neuroses, psychosomatic disorders
insomnia
pain (in combination with analgesics).
Use during pregnancy and lactation
Chlorprotixen should not, if possible, be prescribed to pregnant women and during breastfeeding.
Composition
1 film-coated tablet sheath, contains:
Active ingredient: chlorprotixen hydrochloride 15 mg,
Excipients: to corn starch – 10 mg, lactose monohydrate – 92 mg, sucrose – 10 mg, calcium stearate – 1.5 mg, talc – 1.5 mg.
Film composition: hypromellose 2910/5 – 2.011 mg, macrogol 6000 – 0.069 mg, macrogol 300 – 0.49 mg, talc – 1.43 mg, aluminum varnish based on the yellow sunset dye (E110) – 1 mg.
Dosage and Administration
Psychoses, including schizophrenia and manic conditions.
Treatment begins with 50-100 mg / day, gradually increasing the dose until the optimal effect is achieved, usually up to 300 mg / day. In some cases, the dose can be increased to 1200 mg / day. The maintenance dose is usually 100-200 mg / day. The daily dose of Chlorprotixen Zentiva is usually divided into 2-3 doses, given the pronounced sedative effect of Chlorprotixen Zentiva, it is recommended to prescribe a smaller part of the daily dose in the daytime, and most in the evening.
Hangover withdrawal syndrome in alcoholism and drug addiction.
The daily dose, divided into 2-3 doses, is 500 mg. The course of treatment usually lasts 7 days. After the disappearance of manifestations of withdrawal symptoms, the dose gradually decreases. A maintenance dose of 15-45 mg / day allows you to stabilize the condition, reduces the risk of developing another binge.
In elderly patients, in the presence of hyperactivity, irritability, agitation, confusion, 15-90 mg / day is prescribed. The daily dose is usually divided into 3 doses.
In children, for the correction of behavioral disorders, Chlorprotixen Zentiva is prescribed at a rate of 0.5-2 mg / kg body weight.
Depressive states, neuroses, psychosomatic disorders.
Chlorprotixen Zentiva can be used for depression, especially combined with anxiety, stress, as an adjunct to antidepressant therapy or alone. Chlorprotixen Zentiva can be prescribed for neurosis and psychosomatic disorders, accompanied by anxiety and depressive disorders up to 90 mg / day. The daily dose is usually divided into 2-3 doses. Since taking Chlorprotixen Zentiva does not cause addiction or drug dependence, it can be used for a long time.
Insomnia. 15-30 mg in the evening 1 hour before bedtime.
pain. The ability of Chlorprotixen Zentiva to potentiate the effect of analgesics can be used in the treatment of patients with pain. In these cases, Chlorprotixen Zentiva is prescribed together with analgesics in doses of 15 to 300 mg.
Side effects
Drowsiness, tachycardia, dry mouth, excessive sweating, difficulty in accommodation. These side effects, usually occurring at the beginning of therapy, often disappear as it continues.
Orthostatic hypotension may occur, especially when using Chlorprotixen in high dosages.
Dizziness, dysmenorrhea, skin rashes, constipation are rare. Extrapyramidal symptoms are especially rare.
Isolated cases of lowering the seizure threshold, the occurrence of transient benign leukopenia and hemolytic anemia are described.
With prolonged use, especially in high doses, can be observed: cholestatic jaundice, galactorrhea, gynecomastia, decreased potency and / or libido, increased appetite, increased body weight.
Drug Interaction
The inhibitory effect of chloroprothixene on the CNS may be enhanced with concomitant administration with ethanol and ethanol-containing drugs, anesthetics, opioid analgesics, sedatives, hypnotics, neuroleptics.
The anticholinergic action of chlorprothixene is enhanced by the simultaneous use of anticholinergic, antihistamines and antiparkinsonian agents.
The drug enhances the action of antihypertensives.
Concurrent administration of chlorprothixene and adrenaline can lead to hypotension and tachycardia.
The use of chlorprothixene leads to a decrease in the seizure threshold, which requires additional dose adjustment of antiepileptic drugs in patients with epilepsy.
The ability of chlorprothixene to block dopamine receptors reduces the effectiveness of levodopa.
Extrapyramidal disorders may occur with the concomitant use of phenothiazines, metoclopramide, haloperidol, and reserpine.
Overdose
Symptoms. Drowsiness, hypo- or hyperthermia, extrapyramidal symptoms, convulsions, shock, coma.
Treatment. Symptomatic and supportive. Gastric lavage should be performed as soon as possible, the use of sorbent is recommended. Steps must be taken to maintain the activity of the respiratory and cardiovascular systems. Do not use adrenaline because this can lead to a subsequent decrease in blood pressure. Seizures can be stopped with diazepam and extrapyramidal disorders with biperiden.
Storage conditions
In the dark place at a temperature of no higher than 25 ° C.
The Expiration of
is 3 years.
Active substance
Chlorproti xen
Terms of delivery from
pharmacies Prescription
dosage form
Formulation
tablets
