Description
Release form
Tablets.
Packing
30 pcs.
Pharmacological action of
Kamiren has hypotensive, vasodilating, hypolipidemic, antispasmodic effect. Selectively blocks postsynaptic alpha1-adrenergic receptors. Reduces OPSS, total cholesterol, LDL and triglycerides and increases the content of HDL in serum. Prevents the development of atherosclerosis and coronary heart disease, inhibits platelet aggregation. Camiren reduces the mass of the left ventricle (with prolonged treatment). It prevents the contraction of the smooth muscles of the upper urethra and the muscles of the prostate gland, facilitates urination and eliminates the dysuric symptoms accompanying benign prostatic hyperplasia.
Contraindications
Hypersensitivity, including to other quinazoline derivatives (prazosin, terazosin) or to other Camiren components, gastrointestinal or esophageal obstruction, narrowing of the gastrointestinal tract of any degree, children’s age.
Use during pregnancy and lactation
Pregnant women can be prescribed the drug only for health reasons, when the benefits to the mother outweigh the potential risk to the fetus / baby. The safety of the drug in infants has not been established, therefore, nursing mothers are advised to stop feeding during the treatment with doxazosin.
Special instructions
Special caution should be exercised when prescribing this drug to patients with impaired liver function, especially in cases when drugs are used at the same time, capable of adversely affecting liver function. In cases of deterioration of the functional state of the liver, the drug is immediately canceled.
In order to prevent orthostatic reactions, patients should avoid sudden and abrupt changes in body position (moving from a lying position to a standing position).
Alcohol intake can increase adverse reactions.
Safety and efficacy of doxazosin in children have not been established, therefore, it is not recommended to prescribe the drug to children.
The effect of the “first” administration of the drug is especially pronounced against the background of previous diuretic therapy and a sodium-restricted diet.
Before starting therapy, it is necessary to exclude cancerous degeneration of the prostate gland.
Due to Since doxazosin is able to cause orthostatic reactions at the beginning of treatment or during a period of increasing dosages, it is advisable for patients to refrain from all potentially dangerous activities, in particular from driving motor vehicles and other vehicles and mechanisms.
Composition
1 tablet contains 2 mg doxazosin.
Dosage and administration
Kamiren is taken orally, regardless of food intake.
Arterial hypertension and benign prostatic hyperplasia in patients with arterial hypertension: the initial dose (in the evening before bedtime) is 1 mg per day with a gradual increase to 2, 4 and 8 mg once a day with an interval of 1-2 weeks. The usual daily dose of Camiren is 2-8 mg, the maximum is 16 mg. Benign prostatic hyperplasia in patients with normal blood pressure: the initial dose (sverlkp at night) of 1 mg / day with a gradual increase to 2, 4 and 8 mg once a day (interval – 1-2 weeks). The average daily dose is 2-4 mg, the maximum is 8 mg.
Side effects of
Arterial hypertension
In clinical trials, orthostatic hypotension, which in rare cases can lead to fainting, was most often observed, especially at the beginning of treatment.
General reactions: asthenia, fatigue, malaise.
From the cardiovascular system: swelling, fainting.
Eliminating the alpha-adrenostimulating effects of epinephrine can lead to tachycardia and arterial hypotension.
Overdose
Symptoms: excessive arterial hypotension, dizziness, fainting is possible.
Treatment: In most cases, a dose reduction or temporary interruption of therapy is sufficient. The patient should be given a supine position with a low headboard and slightly raised legs. It is not recommended to induce vomiting. To remove the non-absorbed drug from the gastrointestinal tract, gastric lavage should be performed, activated charcoal, a laxative should be prescribed. Agonists of -Adrenoreceptors (e.g., norepinephrine) are prescribed. Hemodialysis is ineffective (since doxazosin is almost completely bound to plasma proteins).
Storage Conditions
In a dark place at a temperature not exceeding 25 ° C.
The Expiration of
is 3 years.
active substance
Doxazosin
Pharmacy Conditions
Prescription
lekarstvennaja form
tablets
KRKA d.d. Novo mesto AO, Slovenia
