Description
Latin name
cialis
Release form
Film-coated tablets.
Packaging
In the package 4 pcs.
The pharmacological effect of
Cialis is a treatment for erectile dysfunction (impotence, erection disorders) in men and is part of a group of drugs called PDE-5 inhibitors (type 5 phosphodiesterase).
The drug dilates the blood vessels of the penis during sexual arousal. As a result, blood circulation in the penis is enhanced, and this, in turn, contributes to the onset of a stable erection.
Indications
Erectile dysfunction.
Contraindications
Concomitant use of preparations containing any organic nitrates.
Age to 18 years.
Hypersensitivity to the drug.
Special instructions
Caution is necessary when prescribing Cialis to patients taking 1-blockers, for example, doxazosin, since the simultaneous use in some cases can lead to symptomatic arterial hypotension.
In a clinical pharmacology study in 18 healthy volunteers who took a single dose of tadalafil, no symptomatic arterial hypotension was observed with the simultaneous administration of 1-adrenoblocker tamsulosin.
During treatment with Cialis, patients with moderate renal insufficiency (CC from 31 to 50 ml / min) were more likely to have back pain compared with patients with mild renal failure (CC from 51 to 80 ml / min) or healthy volunteers.
Patients with QC 50 ml / min. The drug should be prescribed with caution. Sexual activity has a potential risk for patients with cardiovascular disease. Therefore, the treatment of erectile dysfunction, including with the use of Cialis, should not be performed in men with heart diseases in which sexual activity is not recommended.
The potential risk of complications during sexual activity in patients with diseases of the cardiovascular system should be considered: myocardial infarction in the last 90 days, unstable angina or angina pectoris occurring during intercourse, chronic heart failure (NYHA class II functional class and above ), developed over the past 6 months, uncontrolled heart rhythm disturbances, arterial hypotension (blood pressure less than 90/50 mm Hg) or uncontrolled arterial hypertension, stroke suffered in the past 6 months.
Cialis should be used with caution in patients with a predisposition to priapism (for example, with sickle cell anemia, multiple myeloma or leukemia) or in patients with anatomical deformation of the penis (for example, during angulation, cavernous fibrosis or Peyronie’s disease).
The patient should be informed of the need to immediately consult a doctor in case of an erection lasting 4 hours or more. Untimely treatment of priapism leads to damage to the tissues of the penis, as a result of this, a long-term loss of potency may occur. Against the background of the use of the drug Cialis, no cases of priapism were reported.
The safety and effectiveness of the combination of Cialis with other treatments for erectile dysfunction have not been studied. Therefore, the use of such combinations is not recommended. Like other PDE5 inhibitors, tadalafil has systemic vasodilating properties, which can lead to a transient decrease in blood pressure.
Before prescribing Cialis, doctors should carefully consider whether patients with their cardiovascular disease will not be undesirable due to such vasodilating effects.
Patients with impaired liver function do not need a special dose selection. Since there are no data from controlled clinical trials on the safety and effectiveness of the use of Cialis in patients with severe liver failure, use the drug in this category of patients with extreme caution and only in case of emergency.
For patients with impaired renal function (CC (creatinine clearance)> 30 ml / min), a special dose selection is not required. During treatment with Cialis, patients with moderate renal insufficiency (CC from 31 to 50 ml / min) were more likely to have back pain compared with patients with mild renal failure (CC from 51 to 80 ml / min) or healthy volunteers .
Patients with CC ² °Ò50 ml / min should be prescribed with caution. Since there are no data from controlled clinical trials on the safety and effectiveness of the use of Cialis in patients with severe renal insufficiency (CC> 30 ml / min), the drug should be used in this category of patients with extreme caution and only if absolutely necessary.
Cialis is not used in patients under 18 years of age.
Composition of
In 1 film-coated tablet contains:
Tadalafil 20 mg.
Excipients:
Lactose monohydrate
Hyprolose (hydroxypropyl cellulose)
Croscarmellose sodium
Microcrystalline cellulose
Magnesium stearate
Sodium lauryl sulfate, yellow trihydroxyhydroxyhydroxyhydroxyhydroxyhydroxyhydroxyhydroxyhydroxydryl
Dosage and administration of
The drug is taken orally. The recommended maximum dose of the drug is 20 mg. The maximum recommended frequency of admission is 1 time / day. Cialis is taken at least 16 minutes before the alleged sexual activity.
Patients can attempt intercourse at any time within 36 hours after taking the drug in order to establish the optimal response time to taking the drug.
Side effects
Side effects are usually mild or moderate in severity, transient and decrease with continued use of the drug.
Most common:
headache (11%)
dyspepsia (7%)
Possibly:
back pain
myalgia
nasal congestion
rushing of the face
Rarely:
swelling of the eyes Very rare:
hypersensitivity reactions (including rashes, urticaria and facial edema, Stevens-Johnson syndrome and exfoliative dermatitis)
arterial hypotension (in patients who have already taken antihypertensive drugs)
hypertension and syncope
abdominal pain and gastroesophageal reflux
hyperhidrosis (excessive sweating)
priapism and delayed erection, blurred vision
non-arterial neurotransmission -vascular system:
in patients with cardiovascular risk factors – myocardial infarction
sudden cardiogenic death
stroke, chest pain
palpitations and ta chicardia
However, it is not possible to accurately determine whether these phenomena are directly related to these risk factors, to tadalafil, to sexual arousal, or to a combination of these or other factors.
Overdose
Symptoms: when administered once to healthy volunteers at a dose of 500 mg / day and to patients with erectile dysfunction – repeatedly up to 100 mg / day, undesirable effects were the same as when using the drug in lower doses.
Treatment: conduct standard symptomatic therapy. With hemodialysis, tadalafil is practically not excreted.
Storage conditions
Do not store above 30 ° C.
The Expiration of
is 3 years.
Active ingredient
tadalafil
The dosage form of
tablet
Lilly del Caribe Inc.-Lilly S.A., USA
