Description
Release form
Suspension for oral administration
Packaging
Bottle 20 ml.
Pharmacological action
Nemozole – an anthelmintic drug. The main mechanism of action is associated with an inhibitory effect on the polymerization of beta-tubulin, which leads to the destruction of the cytoplasmic microtubules of the cells of the intestinal tract of helminths, changes the course of biochemical processes (inhibits glucose utilization), blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, causing their death. Most active against larval forms of cestodes – Echinococcus granulosus and Taenia solium, nematodes – Strongyloides stercolatis.
Pharmacokinetics
Absorption and distribution of
After oral administration, it is poorly absorbed from the gastrointestinal tract, unchanged, it is not detected in blood plasma. Oral bioavailability is low, about 30%. Admission simultaneously with fatty foods increases the absorption and the value of Cmax in blood plasma by 5 times.
Metabolism and excretion
Albendazole is rapidly biotransformed in the liver into a primary metabolite – albendazole sulfoxide, which also has anthelmintic activity. Cmax of albendazole sulfoxide in blood plasma is achieved in the range from 2 to 5 hours, binding to plasma proteins is 70%. Albendazole sulfoxide is almost completely distributed throughout the body and is found in urine, bile, liver, in the wall of the cyst and cystic fluid, and cerebrospinal fluid.
Albendazole sulfoxide in the liver is converted to albendazole sulfone (a secondary metabolite) and other oxidized products. T1 / 2 albendazole sulfoxide – 8-12 hours. It is excreted in the form of various metabolites in the urine.
Pharmacokinetics in special clinical cases
Elimination of albendazole and its main metabolite does not change with impaired renal function.
In patients with impaired liver function, bioavailability is increased, Cmaxalbendazole sulfoxide in blood plasma is increased by 2 times, T1 / 2 is prolonged. Albendazole is an inducer of microsomal enzymes of the cytochrome P450 system that accelerates the metabolism of many drugs.
Indications
nematodosiss (ascariasis, enterobiasis, hookworm, necatoriasis, trichuriasis)
mixed helminthic infestations
strongyloidiasis
neurocysticercosis caused by the larval form of Taenia solium
echinococcosis liver, lung, peritoneum, caused by the larval form of Echinococcus granulosus
giardiasis
toxocariasis
as an aid in the surgical treatment of echinococcosis cysts.
Contraindications
retinal damage
pregnancy
hypersensitivity to the drug and other benzimidazole derivatives.
Use with caution in cases of impaired blood formation, impaired liver function (liver function should be regularly monitored before and during treatment), during breastfeeding.
Special instructions
In case of neurocysticercosis, appropriate therapy with corticosteroids and anticonvulsants should be given. GCS for oral or intravenous administration is used to prevent a hypertensive attack in the first week of anticystic therapy.
Control of laboratory parameters
Against the background of the use of the drug, it is recommended to control the cellular composition of the blood. If leukopenia occurs, therapy is stopped.
Blood tests should be performed at the beginning of each 28-day cycle every 2 weeks during albendazole therapy. It is possible to continue treatment with albendazole if the decrease in the total content of leukocytes and neutrophilic leukocytes is moderate and does not progress.
Composition of
5 ml of suspension contains:
Active ingredient: albendazole 100 mg
Excipients: microcrystalline cellulose, sodium carboxymethyl cellulose, glycerin (glycerol), benzoic acid, potassium hydrochloride, sorbicolibenes, sorbicoliben, 80 sorbicoliben, sorbicoliben, poliscorbisolorbis, sorbicoliben, 80 sorbite aroma, essence of ice cream, purified water.
Dosage and administration
The average therapeutic dose for the treatment of nematodoses for adults and children over 2 years of age is 400 mg once or twice a day.
The drug is taken with meals. It is recommended to conduct simultaneous treatment of all family members.
With neurocysticercosis and echinococcosis, patients weighing 60 kg or more are prescribed 400 mg 2 times a day with a body weight of less than 60 kg, the dose is set at 15 mg / kg / day in 2 divided doses. The maximum daily dose is 800 mg (400 mg 2 times a day). The course of treatment for neurocysticercosis is 8-30 days with echinococcosis – 3 cycles of 28 days with a 14-day interval between cycles.
With giardiasis for children, the drug is prescribed at the rate of 10-15 mg / kg 1 time per day for 5-7 days.
In case of toxocariasis, adults and children over 14 years of age with a body weight of more than 60 kg are prescribed 400 mg 2 times a day with a body weight of less than 60 kg – 200 mg 2 times a day for children under 14 years of age, the dose is set at 10 mg / kg 2 times per day. The duration of therapy is 7-14 days.
Side effects of the digestive system
: impaired liver function with a change in liver function tests (mild or moderate increase in transaminase activity), abdominal pain, nausea, vomiting.
From the hemopoietic system: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia.
From the side of the central nervous system: headache, dizziness, meningeal symptoms.
Dermatological reactions: reversible alopecia, skin rash, itching.
Other: fever, increased blood pressure, acute renal failure, allergic reactions.
Drug interaction
When combined with albendazole, dexamethasone and cimetidine increase the concentration of albendazole sulfoxide in the blood.
Overdose
Treatment: gastric lavage, activated charcoal. If necessary, conduct symptomatic therapy.
Storage conditions
In a dry, dark place below 25 ° C
shelf life
3 years
Deystvuyushtee substance
Albendazole
Terms of dispatch from
pharmacies Prescription from
Possible product names
Nemozole suspension 100 mg / 5 ml, 20 ml
NEMOSOL 0.1 / 5ML 20ML SUSP
NEMOSOL 0.1 / 5ML 20ML FLAC SUSP
Nemozol 100mg / 5ml ingest 20ml.
NEMOZOL 100MG / 5ML. 20ML. SUSP.
