isosorbide mononitrate – Pectrol tablets retard 40 mg 30 pcs

$17.00

Description

Release form extended-release tablet.

Packing

30 pcs.

Pharmacological action

Peripheral vasodilator with a primary effect on venous vessels.

Pectrol stimulates the formation of nitric oxide (endothelial relaxing factor) in the vascular endothelium, causing activation of intracellular guanylate cyclase, the consequence of which is an increase in cGMP (mediator of vasodilation). Vasodilation reduces the venous return to the heart (preload), reducing the load on the heart, which reduces the oxygen demand of the myocardium. The dilating effect of nitrates on arteries and arterioles reduces OPSS (afterload).

Pectrol has a coronary expansion effect. Reduces blood flow to the right atrium, helps to reduce pressure in the pulmonary circulation and regression of symptoms in pulmonary edema. Promotes redistribution of coronary blood flow in an area with reduced blood supply.

Pectrol increases exercise tolerance in patients with coronary artery disease, angina pectoris. Expands the vessels of the brain, dura mater, which may be accompanied by a headache. It inhibits platelet aggregation, reduces platelet thromboxane synthesis.

As with other nitrates, cross tolerance develops. After cancellation (interruption of treatment), sensitivity is quickly restored. The antianginal effect occurs 30-40 minutes after ingestion and lasts up to 8-10 hours.

Indications

Prevention of angina attacks in patients with coronary heart disease

Chronic heart failure (as part of combination therapy).

Contraindications

Hypersensitivity to nitrates or other components of the drug.

Arterial hypotension and hypovolemia (systolic blood pressure below 100 mmHg, diastolic blood pressure below 60 mmHg, central venous pressure below 4-5 mmHg)

Acute heart failure

Shock

Vascular collapse

Left ventricular failure with low end diastolic pressure

Acute myocardial infarction (with severe arterial hypotension)

Cardiac tamponade

Toxic pulmonary edema

Diseases

Accompanied by increased intracranial pressure (including hemorrhagic stroke, traumatic brain injury)

Lactation

Age up to 18 years (efficacy and safety not established).

Precautions:

Mitral valve prolapse

Aortic and / or mitral stenosis

tendency to orthostatic disorders vascular regulation

Constrictive pericarditis

elderly age

Severe anemia

Thyrotoxicosis

Hypertrophic cardiomyopathy (possibly increased frequency of angina attacks)

renal failure

Hepatic insufficiency ( risk of methemoglobinemia).

Special instructions

Pectrol is not intended to relieve an attack of angina pectoris.

Proper use of isosorbide mononitrate ensures a period with a low concentration of nitrate, what is necessary to prevent the development of tolerance to nitrates.

As with all nitrates, it is important to strictly follow the instructions for dosing Pectrol and observe the 12-hour interval between doses. In this case, a period of low concentration is achieved.

Composition

Active ingredient:

Isosorbide-5-mononitrate 40.0 mg.

Excipients:

Hypromellose

Carnauba wax

Purified stearic acid

Lactose monohydrate

Magnesium stearate

Silicon dioxide

talc

iron red Titanium

iron red

Dosage and administration of

Pectrol is taken orally after a meal, swallowed whole and washed down with a glass of water. The usual initial dose is 40 mg once a day (in the morning). The dose of the drug can be increased to 60 mg once a day or up to 80 mg (40 mg 2 times a day).

Side effects of

From the cardiovascular system: “nitrate” headache, dizziness, transient hyperemia of the facial skin, sensation of heat, tachycardia, marked decrease in blood pressure (BP). In rare cases, increased angina attacks (paradoxical reaction), orthostatic collapse.

From the gastrointestinal tract: nausea, vomiting, there may be a sensation of a light burning sensation of the tongue, dry mouth

From the central nervous system: stiffness, drowsiness, blurred vision, decreased ability to quickly psychic and motor reactions (especially at the beginning of treatment). In rare cases, cerebral ischemia.

Allergic reactions: skin rash, in some cases – exfoliative dermatitis.

Others: development of tolerance (including cross-tolerance to other nitrates).

Drug interaction

Pectrol ® with simultaneous use increases the concentration of dihydroergotamine in the blood.

Barbiturates accelerate biotransformation and reduce the concentration of isosorbide mononitrate in the blood.

When used together with antihypertensive drugs, vasodilators, antipsychotics (antipsychotics), tricyclic antidepressants, novocainamide, ethanol, quinidine, beta-blockers, slow calcium channel blockers, dihydroergotamine and sildenafil may increase the hypotensive effect.

With a combination of amiodarone, propranolol, slow calcium channel blockers (including verapamil, nifedipine), acetylsalicylic acid and Pectrol, an antianginal effect may be enhanced.

Under the influence of beta-adrenostimulants, alpha-blockers (including dihydroergotamine), a decrease in the severity of the antianginal effect (tachycardia, an excessive decrease in blood pressure) is possible.

When combined with m-anticholinergics (including atropine), the likelihood of increased intraocular pressure increases.

Adsorbents, astringents and enveloping agents reduce the absorption of isosorbide-5-mononitrate in the digestive tract.

Overdose

Symptoms: headache, dizziness, palpitations, hyperthermia, hyperemia of the skin, sweating, nausea, vomiting, diarrhea, methemoglobinemia (cyanosis, anoxia), hyperpnea, dyspnea, cerebrospinal pressure, cerebrospinal pressure, cerebrospinal pressure, cerebrospinal pressure, fainting, paralysis, coma.

Treatment: gastric lavage, with methemoglobinemia – inside or in / in ascorbic acid – 1 g, in / in 1% solution of methylene blue 1-2 mg / kg in severe arterial hypotension – in / in phenylephrine (mesatone). Epinephrine and its related compounds are ineffective.

Storage Conditions

In a dark place at a temperature not exceeding 25 ° C.

Deystvuyuschee substances

isosorbide mononitrate

Dosage form

tablet prolong.

Indications

Hronycheskaya failure circulation, angina

KRKA d.d. Novo mesto AO, Slovenia