Description
Latin name
Ursosan
Release form
Capsules.
Packing
100 pcs
Indications
Uncomplicated gallstone disease (biliary sludge dissolving cholesterol gallstones in the gallbladder, if it is impossible to remove them by surgical or endoscopic methods, prevention of stone formation recurrence after cholecystectomy)
chronic active hepatitis srdl acute medicinal) liver lesions
alcoholic liver disease
non-alcoholic steatohepatitis
primary biliary cirrhosis
primary sclerosing cholangitis
cystic fibrosis (cystic fibrosis) liver
atresia of the intrahepatic bile ducts and bile ducts gastritis and reflux esophagitis
biliary dyspeptic syndrome (with cholecystopathy and biliary dyskinesia)
prevention of liver damage when using hormones tional contraceptives and cytostatics.
Contraindications
X-ray positive (high calcium) gallstones
non-functioning gallbladder
biliary and gastrointestinal fistula
acute cholecystitis
acute cholangitis sr diseases of the gallbladder and bile ducts
empyema of the gallbladder
hypersensitivity to the components of the drug.
Ursosan is used with caution: in children aged 2 to 4 years, as it may be difficult to swallow capsules, although ursodeoxycholic acid has no age-related restrictions on use.
Use during pregnancy and lactation
The use of ursodeoxycholic acid during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus (adequate, strictly controlled studies on the use of ursodeoxycholic acid in pregnant women have not been conducted).
There are currently no data on the release of ursodeoxycholic acid in breast milk. If it is necessary to use ursodeoxycholic acid during lactation, the issue of stopping breastfeeding should be addressed.
Dosage and administration
Ursosan capsules are taken orally with plenty of water.
Prescription for diffuse liver diseases, gallstone disease
For diffuse liver diseases, gallstone disease (cholesterol gallstones and biliary sludge), the drug is prescribed continuously for a long time (from several months to several years) in a daily dose of 10 mg / kg body weight to 12-15 mg / kg (2-5 caps.).
Prescription for diffuse liver diseases
For diffuse liver diseases, the daily dose of Ursosan is divided into 2-3 doses, the capsules are taken with food.
Prescription for gallstone disease
In gallstone disease, the entire daily dose is taken once a night. The duration of taking the drug to dissolve the stones is until complete dissolution, and then another 3 months for the prevention of relapse of stone formation.
Appointment for biliary reflux gastritis and reflux esophagitis
For biliary reflux gastritis and reflux esophagitis, the drug is prescribed 250 mg (1 caps. ) per day, before bedtime. The course of treatment is from 10-14 days to 6 months, if necessary – up to 2 years.
Purpose for the prevention of re-cholelithiasis after cholecystectomy
After cholecystectomy, for the prevention of re-cholelithiasis, the recommended dose is 250 mg 2 times / day for several months.
Prescribing for toxic, medicinal liver damage, alcoholic liver disease and biliary atresia
For toxic, medicinal liver damage, alcoholic liver disease and biliary atresia, the daily dose is set at 10-15 mg / kg / in 2-3 doses. The duration of therapy is 6-12 months or more.
Prescription for primary biliary cirrhosis
For primary biliary cirrhosis, the drug is prescribed at a rate of 10-15 mg / kg / day (if necessary, up to 20 mg / kg) in 2-3 doses. The duration of therapy is from 6 months to several years.
Prescribing for primary sclerosing cholangitis
For primary sclerosing cholangitis – 12-15 mg / kg / day (up to 20 mg / kg) in 2-3 doses. The duration of therapy is from 6 months to several years.
Prescribing for non-alcoholic steatohepatitis
For non-alcoholic steatohepatitis – 13-15 mg / kg / day in 2-3 doses. The duration of therapy is from 6 months to several years.
Prescription for cystic fibrosis
In cystic fibrosis, the dose is set at the rate of 20-30 mg / kg / day in 2-3 doses. The duration of therapy is from 6 months to several years.
Prescribing in children over the age of 2 years
For children over the age of 2 years, the dose of the drug is set individually at the rate of 10-20 mg / kg / day.
Side effects of the digestive system: nausea, vomiting, diarrhea (may be dose-dependent), constipation, transient (transient) increased activity of hepatic transaminases (AST, ALT) rarely – calcification of gallstones.
Other: back pain, allergic reactions, exacerbation of previously existing psoriasis, alopecia is rare – calcification of gallstones.
Drug Interaction
Reduction of UDCA absorption – when combined, aluminum-containing antacids and ion-exchange resins (colestyramine) reduce UDCA absorption.
Decrease in ability of UDHK to dissolve cholesterol bilious concretions – at a concomitant use of lipid-lowering drugs (especially clofibrate), estrogens, neomycin or progestins increase bile saturation with cholesterol and can reduce the ability of UDLC to dissolve cholesterol.
Overdose
There are no known cases of overdose with ursodeoxycholic acid.
Storage conditions
Store in a dry, dark place at a temperature of 15-25 ° C.
Keep out of the reach of children.
Expiration
4 years.
Deystvuyuschee substances
ursodeoxycholic acid
Dispensing from pharmacy ddpfafaf19971715045050 Presfd50 from
pharmacies Prescription
Dosage form
dosage form
capsules
PRO MED MEDIA Prague, Russia
