Description
Description
Cream for external application of white or almost white color, uniform, without small, large and foreign particles, without signs of separation.
Latin name
ZOVIRAX
Production form
5 g – aluminum tubes (1) – packs of cardboard.
Pharmacological action
Antiviral drug for external and local use. Acyclovir is active against Herpes simplex types 1 and 2, Varicella zoster virus, Epstein-Barr virus and cytomegaloviruses.
The thymidine kinase of virus-infected cells through a series of sequential reactions actively converts acyclovir to acyclovir mono-, di- and triphosphate. The latter interacts with viral DNA polymerase and integrates into DNA, which is synthesized for new viruses. Thus, defective viral DNA is formed, which leads to suppression of replication of new generations of viruses.
Indications
Infections of the skin and mucous membranes caused by Herpes simplex virus types 1 and 2, incl. herpes lips.
Contraindications
Hypersensitivity to acyclovir and other components of the drug.
Use during pregnancy and lactation
Adequate and strictly controlled clinical studies of the safety of the drug during pregnancy have not been conducted.
Use is indicated only in cases where the intended benefit to the mother outweighs the potential risk to the fetus.
Ingredients
100 g of cream contains:
Active ingredient:
Acyclovir 5 g.
Excipients:
Propylene glycol,
white soft paraffin,
cetostearyl alcohol,
liquid paraffin,
poloxamer 407 sodium,
lauryl sulfate,
dimethicone, srdlk.
Dosage and administration
The drug is recommended to be applied 5 times / day (approximately every 4 hours) with a thin layer on the affected and adjacent areas of the skin and mucous membranes.
Duration of treatment – at least 4 days. In the absence of healing, treatment can be continued for up to 10 days. If symptoms persist for more than 10 days, you should consult your doctor.
The cream is applied either with a cotton swab or with clean hands to avoid additional infection of the affected areas.
Side effects
Local reactions: sometimes – short-term redness, itching, peeling, burning or tingling in the areas of application of the drug.
Allergic reactions: rarely – allergic dermatitis (often associated with a reaction to excipients) in isolated cases – Quincke’s edema.
Drug interaction
No interaction of Zovirax ® with other drugs has been detected.
Overdose
There is no data on an overdose of Zovirax ®.
Storage conditions
The drug should be stored out of the reach of children at a temperature not higher than 25 ° C. Do not freeze.
Expiration
3 years.
Deystvuyuschee substances
acyclovir
over-the-counter
pharmacies over-the-counter
Formulation
Formulation
cream
GlaxoSmithKline, UK
