Description
Release form
Gel for external use.
Packaging
100 g
Pharmacological action
Pharmacodynamics
NSAIDs, a derivative of propionic acid. It has an analgesic, anti-inflammatory effect.
Inhibiting COX-1 and COX-2, inhibits the synthesis of prostaglandins. It has anti-bradykinin activity, stabilizes lysosomal membranes. Reduces the release of cytokines, inhibits the activity of neutrophils.
With joint syndrome, it reduces pain in joints at rest and during movement, reduces morning stiffness and swelling of joints, and helps to increase range of motion.
Pharmacokinetics
Absorption
With external use of the gel, an extremely slow transdermal absorption of ketoprofen occurs, which ensures the maintenance of its concentration in inflamed tissues within the therapeutic level for a long time. Absorption into the systemic circulation is negligible. Almost does not cumulate. The bioavailability of the gel is about 5%.
Distribution
Ketoprofen penetrates well into synovial fluid and connective tissue.
Indications
Inflammatory or traumatic lesions of the joints, tendons, ligaments and muscles:
arthritis, periarthritis
tendonitis, tendosynovitis
bursitis
bruises, ligament injuries, dislocations, injuries of the laparissa knee srd.
Phlebitis, peripheralitis.
Contraindications
Hypersensitivity to ketoprofen or other components of the drug
dermatosis
eczema
infected abrasions and wounds
pregnancy and lactation
childhood.
Use during pregnancy and lactation
The drug is contraindicated in pregnancy and lactation.
Composition of
1 g of gel contains:
Active substances:
ketoprofen 25 mg.
Excipients:
ethanol (ethyl alcohol) rectified,
nipagin,
carbomer,
trometamol,
lavender oil,
neroli oil,
purified water.
Dosage and administration
The drug is applied to the skin of the painful area 2 times / day, squeezing about 3-5 cm of gel or more from the tube (depending on the area of the painful area), spread in a uniform thin layer and gently rub until completely absorbed.
In order to increase the effectiveness of therapy, it is possible to use a gel under a dry occlusive dressing.
Side effects
In rare cases: allergic reactions that require discontinuation of the drug, photosensitivity.
Drug Interaction
No drug interactions of Bystrumgel® with other medicinal products have been reported at this time.
Overdose
Overdose has not been reported with Bystrumgel®.
Storage conditions
Store in a dry, dark place.
Expiration
2 years.
Deystvuyuschee substances
Ketoprofen
Dosage form
Dosage form
gel for external use
Akrikhin CPC JSC, Russia
