Description
Release form
Lyophilisate for solution for intramuscular administration.
Packing
10 pcs.
Pharmacological action of
chondroitin sulfate – the main component of proteoglycans, constituting the cartilage matrix together with collagen fibers. Artradol has chondroprotective properties. Suppresses the activity of enzymes that cause degradation of articular cartilage. Stimulates the production of proteoglycans by chondrocytes. Enhances metabolic processes in the cartilage and subchondral bone. It has an effect on phosphorus-calcium metabolism in cartilage. The drug has anti-inflammatory and analgesic properties, helps to reduce the release of inflammatory mediators and pain factors into the synovial fluid through synoviocytes and macrophages of the synovial membrane, and inhibits the secretion of leukotriene B4 and prostaglandin E2. The drug helps to restore the cartilage surfaces of the joints, prevents the collapse of connective tissue. Normalizes the production of articular fluid, leading to better joint mobility and less pain. With structural similarities to heparin, Artradol can inhibit the formation of fibrin blood clots in the synovial and subchondral microvasculature.
Indications
Artradol – a drug for the treatment of degenerative diseases of the joints and spine: primary arthrosis, osteoarthritis with damage to large joints, intervertebral osteochondrosis.
Contraindications
Hypersensitivity, children’s age (efficacy and safety not established).
Use with caution in case of bleeding, tendency to bleeding, and thrombophlebitis. As well as during pregnancy and lactation.
Composition of
1 ampoule contains 100 mg of chondroitin sulfate
Dosage and Administration
Artradol is administered intramuscularly, 0.1 g every other day. Before use, the contents of the ampoule are dissolved in 1 ml of water for injection. With good tolerance, the dose is increased to 0.2 g, starting with the 4th injection. The course of treatment is 25-35 injections. Repeated course – after 6 months. The duration of repeated courses of treatment is determined by the doctor.
Side effects
Allergic reactions, hemorrhages at the injection site.
Drug interaction
It is possible to enhance the action of indirect anticoagulants, antiplatelet agents, fibrinolytics, which requires more frequent monitoring of blood coagulation when used together.
Storage conditions
In a dry, dark place at a temperature of no higher than 20C.
active substance
Chondroitin sulfate
Terms and conditions
prescription
Dosage form
injection solution
Indications
osteochondrosis, osteoarthritis, arthritis, osteoarthritis
