Description
Latin name
Chloropyraminum
Release form
Solution for intramuscular and intravenous administration.
Packing
5 ampoules of 1 ml.
Pharmacological action
Chloropyramine has antiallergic and antipruritic effects.
Pharmacodynamics
Chloropyramine is a blocker of H1 receptors. By chemical structure, it refers to ethylenediamine derivatives. Chloropyramine selectively inhibits histamine H1 receptors and reduces capillary permeability. Prevents development and facilitates the course of allergic reactions. It has a sedative and pronounced antipruritic effect. It has a moderate peripheral anticholinergic and antispasmodic activity and antiemetic effect.
Pharmacokinetics
Absorption: Blood concentration reaches a maximum for 2 hours and remains at the therapeutic level for 4 to 6 hours.
Distribution: Evenly distributed in the body, crosses the blood-brain barrier. The connection of chloropyramine with plasma proteins is 7.9%. The peak binding was observed at pM 6.8-7.4.
Excretion: Metabolized in the liver, excreted mainly through the kidneys with urine in the form of metabolites.
Indications
Allergic diseases, including:
urticaria,
rhinitis,
conjunctivitis,
pollinosis (hay fever),
angioedema,
disease
contact dermatitis,
itchy skin,
neurodermatitis,
toxicoderma.
Contraindications
Individual hypersensitivity to the drug Chloropyramine.
Concomitant use of monoamine oxidase inhibitors.
Newborn babies.
Pregnancy and lactation.
Peptic ulcer in the acute stage.
Angle-closure glaucoma.
Prostate hyperplasia.
Respiratory failure.
The drug should be prescribed with caution to elderly patients, with insufficient liver function and / or heart disease, with peptic ulcer of the gastrointestinal tract, while taking medications that inhibit the central nervous system.
Special instructions
Alcoholic beverages are not allowed during treatment.
Taking the drug overnight can increase the symptoms of reflux esophagitis.
If, during prolonged use of the drug, an unreasonable increase in body temperature, laryngitis, pallor of the skin, jaundice is observed, the formation of ulcers of the oral mucosa, the appearance of hematomas, unusual and difficult to stop bleeding, you must consult a doctor, since prolonged therapy with antihistamines can lead to impaired hematopoiesis.
Antihistamines can distort the reaction when staging skin allergy tests, so the drug should be discontinued a few days before the planned test.
When combined with ototoxic drugs, chloropyramine may mask early manifestations of ototoxicity.
Influence on the ability to drive vehicles and operate machinery
Patients using chloropyramine are advised to refrain from driving vehicles, working with machinery, as well as from other activities, requiring increased concentration of attention and speed of psychomotor reactions.
Composition of
1 ml of solution for intramuscular and intravenous administration contains: active ingredient: chloropyramine hydrochloride 20 mg
excipient: water for injection
Dosage and Administration
Intramuscularly or intravenously.
Adults are prescribed 20-40 mg per day (contents of 1-2 ampoules).
Treatment in children begins with a dose of 5 mg (0.25 ml). In the future, the dose increase is limited mainly by the appearance of side effects.
Children 1-12 months of age – 5 mg (0, 25 ml).
For children 2-6 years of age, 10 mg (0.5 ml).
For children aged 7-14 years, 10-20 mg (0.5-1 ml).
The daily dose should not exceed 2 mg / kg body weight.
In severe allergies, treatment should be started with an injectable form of chloropyramine. First, it is administered intravenously slowly, then they switch to intramuscular injection and in the final phase of treatment they switch to taking the tablets inside.
Side effects of the
From the central nervous system: lethargy, weakness, drowsiness, dizziness, headache, euphoria, fatigue, irritability, tremor, cramps, impaired coordination of movements, impaired vision in children, there may be some stimulating effect on WYC, manifested by anxiety, increased irritability, insomnia.
From the digestive system: dry mouth, nausea, vomiting, gastralgia, diarrhea / constipation, loss or increase in appetite.
Urinary system: difficulty urinating.
From the cardiovascular system: lowering blood pressure (more often in elderly patients), tachycardia, arrhythmia.
From the hemopoietic system: very rarely – leukopenia, agranulocytosis.
From the side of the organs of vision: increased intraocular pressure.
Other: photosensitization, muscle weakness.
Allergic reactions to the drug.
Drug Interactions
Enhances the effects of drugs for general anesthesia, hypnotics, sedatives, tranquilizers, m-anticholinergics, opioid analgesics, local anesthetics.
Tricyclic antidepressants and MAO inhibitors enhance the m-anticholinergic and inhibitory effect on the central nervous system.
Caffeine and phenamine reduce CNS depressant effects.
Concomitant use with ethanol is not recommended (risk of severe CNS depression).
Overdose
Symptoms: in children – excitement, anxiety, hallucinations, athetosis, ataxia, convulsions, mydriasis, immobility of the pupils, hyperemia of the skin, hyperthermia then – collapse, coma. In adults – depression (inhibition, depression) or excitation of the central nervous system (psychomotor excitation), very rarely-hallucinations, coordination disorder, pupil dilation and lack of reaction to light, dry mouth, hyperthermia and hyperemia of the skin, convulsions, convulsions. cases – coma.
Treatment: symptomatic therapy (including prescription of antiepileptic drugs, caffeine, phenamine), resuscitation, artificial lung ventilation – according to the indications. There is no specific antidote.
Storage conditions
In a dark place at a temperature not exceeding 25 ° C.
Shelf life
3 years.
Deystvuyushtee substance
Hloropiramin
Pharmacy terms
Prescription
Dosage form
injection and infusion
