nifedipine – Corinfar tablets are coated.pl.ob.prolong. action 10 mg 50 pcs

$15.00

Description

Latin name

Corinfar

Release form

Coated tablets.

Packaging

In a dark glass bottle there are 50 coated tablets. In a pack of cardboard 1 bottle.

Indications

– Stable angina pectoris.

– Arterial hypertension.

– Angiospastic angina pectoris (Prinzmetal angina, variant angina pectoris).

Contraindications

– Cardiogenic shock.

– Severe stenosis of the aortic orifice.

– Unstable angina pectoris.

– Acute myocardial infarction.

– Pregnancy.

– Lactation (breastfeeding).

– Hypersensitivity to nifedipine.

Pregnancy and lactation

Corinfar is contraindicated in pregnancy.

If you need to use Corinfar during lactation, you should decide on the termination of breastfeeding.

Composition

1 coated tablet contains: nifedipine 10 mg.

Dosage and administration

Set individually depending on the severity of the disease.

In the treatment of stable and angiospastic angina pectoris and arterial hypertension, the drug is prescribed 10 mg (1 tab.) 2-3 times / day. With insufficient severity of the clinical effect, a gradual increase in dose to 20-40 mg (2-4 tablets) is possible 2 times / day.

The maximum daily dose is 80 mg.

The interval between doses of two single doses of 20 mg (2 tablets) should not be less than 4 hours. If you take the drug twice a day, tablets should be taken after about 12 hours (morning and evening).

The drug should be taken after a meal, without chewing and drinking plenty of fluids.

Side effects of

From the cardiovascular system: tachycardia, palpitations, arrhythmias, peripheral edema (ankles, feet, legs), manifestations of excessive vasodilation (asymptomatic decrease in blood pressure, development or aggravation of heart failure, “to hot flashes” , hyperemia of the skin of the egg, a feeling of fever), a marked decrease in blood pressure (rarely), syncope. In some patients, especially at the beginning of treatment or with an increase in dose, angina attacks may occur in isolated cases – the development of myocardial infarction, which requires discontinuation of the drug.

From the side of the central nervous system: headache, dizziness, general weakness, fatigue, drowsiness. With prolonged use of the drug in high doses – limb paresthesia, tremor, extrapyramidal (parkinsonian) disorders (ataxia, masky face, shuffling gait, tremor of the hands and fingers, difficulty swallowing), depression.

From the digestive system: dyspepsia (nausea, diarrhea or constipation), dry mouth, flatulence, increased appetite. Rarely – gingival hyperplasia, completely disappearing after drug withdrawal. With prolonged use – impaired liver function (intrahepatic cholestasis, increased activity of hepatic transaminases).

From the musculoskeletal system: arthritis, myalgia, swelling of the joints, convulsions of the upper and lower extremities.

Allergic reactions: rarely – skin itching, urticaria, exanthema, autoimmune hepatitis, exfoliative dermatitis, photodermatitis, anaphylactic reactions

From the hemopoietic organs: anemia, leukopenia, thrombocytopenia, thrombocytopenic purpurenica.

From the urinary system: increased daily urine output, impaired renal function (in patients with renal failure).

Other: rarely – visual impairment (including transient blindness with a maximum concentration of nifedipine in the blood plasma), gynecomastia (in elderly patients, disappearing after cancellation), galactorrhea, hyperglycemia, pulmonary edema, bronchospasm, weight gain.

Drug Interaction

When used with Corinth with beta-blockers, diuretics, and other antihypertensive drugs, an increase in the antihypertensive effect of Corinth is noted.

When used with Corinth with nitrates, the anti-anginal effect of Corinth is increased.

With the use of Corinth and tricyclic antidepressants, cimetidine, ranitidine, the effects of Corinth may be enhanced.

With the concomitant use of Corinth with quinidine, a decrease in the concentration of quinidine in the blood plasma was observed in some cases.

With the concomitant use of Corinth with digoxin and theophylline, in some cases a decrease in the concentration of the latter in blood plasma was observed.

Overdose

Symptoms: In severe cases, loss of consciousness until the development of coma, hypotension, tachy / bradycardia, hyperglycemia, metabolic acidosis, hypoxia, cardiogenic shock with pulmonary edema.

Treatment: Abundant gastric lavage, if necessary, in combination with small bowel lavage. The use of laxatives should take into account the decrease in intestinal muscle tone up to the bowel atony observed with the use of calcium channel blockers. Since nifedipine is not excreted in hemodialysis, it is impractical to carry it out. Plasmapheresis is recommended.

At development of a bradycardia it is necessary to appoint atropine and / or beta-sympathomimetics, at the threatening life of the patient of a bradycardia it is necessary to implant the driver of a heart rhythm on time.

In case of arterial hypotension, which is a consequence of cardiogenic shock and expansion of arterial vessels, 1-2 g of calcium gluconate are introduced into / into, in / in a droplet – dopamine (up to 25 mcg / kg body weight / min), dobutamine – up to 15 mcg / kg body weight / min), epinephrine (adrenaline) or norepinephrine (norepinephrine) ). The calcium content of the serum is maintained at a normal or slightly elevated level.

The introduction of fluid or blood into the body is carried out with caution under the control of hemodynamic parameters.

Storage conditions

In the dark place.

Expiration

3 years.

Deystvuyuschee substances

nifedipine

pharmacy terms of prescription

Dosage form

Dosage form

tablets prolong.

Teva Pharmaceutical Enterprises Co., Ltd., Israel