metoclopramide – metoclopramide ampoules 5 mg /ml 2 ml 10 pcs

$15.00

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Description

Latin name

Metoclopramide

Release form

Injection solution

Packing

10 ampoules of 2 ml.

Pharmacological action

Metoclopramide – an antiemetic, helps reduce nausea, hiccups stimulate gastrointestinal motility. The antiemetic effect due to blockade of dopamine D2 receptors and an increase in the threshold of the trigger zone chemoreceptors is a blocker of serotonin receptors. It is believed that metoclopramide inhibits the relaxation of smooth muscle of the stomach caused by dopamine, thereby enhancing cholinergic reactions of the smooth muscles of the gastrointestinal tract. Helps to accelerate the emptying of the stomach by preventing relaxation of the body of the stomach and increasing the activity of the antrum and upper small intestine. Reduces the reflux of contents into the esophagus by increasing the pressure of the sphincter of the esophagus at rest and increases the clearance of acid from the esophagus due to an increase in the amplitude of its peristaltic contractions.

Metoclopramide stimulates prolactin secretion and causes a transient increase in circulating aldosterone, which may be accompanied by short-term fluid retention.

Indications

vomiting, nausea, hiccups of various origins (in some cases it can be effective for vomiting caused by radiation therapy or taking cytostatics)

atony and hypotension of the stomach and intestines (in particular, postoperative)

biliary tract reflex dyskinesia Esophagitis

flatulence

functional pyloric stenosis.

as part of the complex treatment of exacerbations of gastric and duodenal ulcer

is used to enhance peristalsis during X-ray contrast studies of the gastrointestinal tract

as a means, facilitating duodenal sounding (to accelerate the emptying of the stomach and the movement of food through the small intestine).

Contraindications

bleeding from the gastrointestinal tract

stenosis of the pylorus

mechanical intestinal obstruction

perforation of the stomach wall or bowel

pheochromocytoma

epilepsy

glaucoma

extrapyramidal disorders

Parkinson’s disease

prolaktinozavisimye tumor

vomiting during therapy or antipsychotic drugs overdose in patients

breast cancer bronchial asthma in patients with hypersensitivity to

sulfites pregnancy (I trimester), lact period

anions early childhood (for children under 2 years of age – the use of metoclopramide in the form of any dosage forms is contraindicated for children under 6 years of age, parenteral administration is contraindicated)

hypersensitivity to metoclopramide or any of the components of the drug.

Do not prescribe after gastrointestinal surgery (such as pyloroplasty or intestinal anastomosis), since vigorous muscle contractions interfere with healing.

If you are hypersensitive to metoclopramide or other components of the drug, be sure to consult your doctor before taking it.

Precautions: bronchial asthma, arterial hypertension, Parkinson’s disease, renal and / or liver failure, advanced age (over 65 years), childhood (increased risk of developing dyskinetic syndrome).

Pregnancy and lactation

Contraindicated in pregnancy.

When used during lactation (breastfeeding), it should be borne in mind that metoclopramide passes into breast milk.

In experimental studies, no adverse effects of metoclopramide on the fetus were found.

Composition of

1 ml of the solution contains:

Active ingredient: metoclopramide hydrochloride – 5 mg

Excipients: disodium hydrochloric acid and sodium disodium hydrochloric acid for injection.

Method of use and doses

Injection solution is administered intravenously or intramuscularly to adults in a dose of 10 “20 mg (maximum daily dose is 60 mg) for children over 6 years old – 5 mg 1 “3 times a day for children aged 2 to 6 years, the daily dose is 0.5 “1 mg / kg body weight, the frequency of administration is 1-3 times.

For the prevention and treatment of nausea and vomiting due to cytostatics or radiation therapy, the drug is administered intravenously at a dose of 2 mg / kg body weight 30 minutes before the use of cytostatics or irradiation, if necessary, the administration is repeated after 2-3 hours.

Before radiological examination, adults are administered iv 10 “20 mg 5 “15 minutes before start of research.

Patients with clinically severe hepatic-renal failure are initially prescribed a dose 2 times lower than the usual dose, the next dose depends on the patient’s individual response to metoclopramide.

Side effects of the

From the digestive system: at the beginning of treatment, constipation is possible, diarrhea is rare – dry mouth.

From the side of the central nervous system: at the beginning of treatment, a feeling of tiredness, drowsiness, dizziness, headache, depression, akathisia are possible. Extrapyramidal symptoms may occur in children and young adults (even after a single use of metoclopramide): facial muscle spasm, hyperkinesis, spasmodic torticollis (usually go away immediately after stopping metoclopramide). With prolonged use, more often in elderly patients, the phenomena of parkinsonism, dyskinesia are possible.

From the hematopoietic system: agranulocytosis is possible at the beginning of treatment.

From the endocrine system: rarely, with prolonged use in high doses – galactorrhea, gynecomastia, menstrual irregularities.

Allergic reactions: rarely – skin rash.

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Storage Conditions

In a dry, dark place at a temperature not exceeding 25 ° C.

shelf life

3 years

Deystvuyushtee substance

Metoclopramide

dosage form

injection

Possible product names

metoclopramide ampoules 5 mg / ml, 2 ml, 10 pcs.

Novosibkhimpharm, Russia

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