Description
Release form
Granules Magnesium-Diasporal 300 for the preparation of a solution for oral administration.
Packaging
20 packages.
Pharmacological action
Pharmaceutical group: magnesium preparation.
Pharmaceutical action: Magnesium is involved in most metabolic reactions, activates over 300 enzymes. An indispensable element in the processes that ensure the flow and expenditure of energy. Participates in the balance of electrolytes, ion transport, membrane permeability, in the regulation of transmission of nerve impulses and in muscle contraction. It is a natural calcium antagonist.
Pharmacokinetics: Magnesium is slowly and not completely absorbed in the gastrointestinal tract, with malabsorption syndrome and the use of foods rich in fats, magnesium absorption is reduced. An unabsorbed portion of magnesium is secreted through the intestines.
Serum contains about 1% of absorbed magnesium (0.8-1.0 mmol / L). Approximately 45% of magnesium binds to intracellular proteins and macroergic phosphates and is deposited in skeletal muscles, kidneys, liver and myocardium. The remainder is deposited in bone tissue in small quantities – in tissue fluid and red blood cells.
Magnesium ions cross the blood-brain barrier and the placental barrier.
Absorbed magnesium is eliminated by the kidneys, and only a small portion is excreted in the bile and through the sweat glands. Partially resorbed in the renal tubules. The rate of excretion by the kidneys is proportional to the concentration in plasma and the value of glomerular filtration.
Indications
Magnesium deficiency accompanying symptoms such as minor sleep disturbances, increased irritability, weak anxiety, increased fatigue, calf muscle spasm.
Contraindications
Increased individual sensitivity to the components of the drug Magnesium-Diasporal 300, severe renal failure, atrioventricular block, myasthenia gravis, hypermagnesemia, children under 12 years of age.
Due to the presence of sucrose, Magnesium – Diasporal 300 is contraindicated in case of fructose intolerance, impaired glucose or galactose absorption syndrome, or in case of sucrose deficiency – isomaltase.
Caution.
Moderate renal failure (danger of developing hypermagnesemia).
Use during pregnancy and lactation
Use of the drug Magnesium-Diasporal 300 during pregnancy only on the recommendation of a doctor.
Considering that magnesium passes into breast milk, it is recommended that you stop breastfeeding if you need to take the drug.
Special instructions
The preparation Magnesium-Diasporal 300 does not affect the ability to control machines and mechanisms.
Composition
1 packet: – magnesium citrate 1.83 g (respectively magnesium 295.7 mg)
Dosage and Administration
Inside.
Adults and children over 12 years of age – 1 packet of Magnesium-Diasporal 300 daily. Dissolve the contents of 1 packet in 0.5 cups of fruit juice, tea or water.
Typically, the duration of treatment is one month.
Side effects
Allergic reactions, disorders of the gastrointestinal tract are possible: diarrhea, abdominal pain, constipation, nausea, flatulence.
Drug Interactions
Aminoglycoside antibiotics, cisplatin and cyclosporine accelerate the excretion of magnesium.
Ions of magnesium, iron, fluoride and tetracycline mutually affect the absorption of each other, therefore it is necessary to observe a 2-hour interval between taking Magnesium-Diasporal 300 and preparations containing the above substances. Magnesium weakens the effect of indirect anticoagulants, reduces iron absorption.
overdose
Overdose symptoms: decreased blood pressure, nausea, vomiting, slowing reflexes, respiratory depression, coma, cardiac arrest, anuria.
Treatment: In / in administration of calcium and in / m or subcutaneous administration of 1-2 ampoules (0. 5-1 mg / ml) methyl sulfate neostigmine / or oral administration of 0.9% sodium chloride in case of renal failure – hemodialysis or peritoneal dialysis.
Active ingredient
Magnesium citrate
Form of Treatment
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