Description
Latin name
Metrogyl
Packaging
30 g – aluminum tubes (1) – packs of cardboard.
Pharmacological action
Metrogil has an antibacterial, antiprotozoal (trichomonacid) effect.
The nitro group of metronidazole is restored in anaerobic microorganisms and protozoa, interacts with the DNA of microorganism cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Metronidazole is active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia, anaerobic bacteria: Bacteroides spp., Fusobacterium spp.
In combination with amoxicillin, it is active against Helicobacter pylori (amoxicillin inhibits the development of resistance to metronidazole).
Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against conventional aerobes.
Increases the sensitivity of tumors to radiation, causes disulfiram-like reactions, stimulates reparative processes.
When applied topically, it has an anti-acne effect whose mechanism is not exactly known.
Indications
rosacea (including poststeroidal)
vulgar acne
oily seborrhea, seborrheic dermatitis
trophic ulcers of the lower extremities (against varicose veins, sarcosis of the sarcid sarcitis srdlrd) passage
Contraindications
Hypersensitivity to the components of the drug.
Use during pregnancy and lactation
Caution – I trimester of pregnancy, lactation.
Composition
Metronidazole 10 mg
Excipients: methyl parahydroxybenzoate, propyl parahydroxybenzoate, carbomer 940, disodium edetate, sodium hydroxide, propylene glycol, purified water.
Dosage and administration
External use. The gel is applied to previously cleaned skin with a thin layer 2 times a day, morning and evening, for 3-9 weeks. If necessary, apply an occlusive dressing. The average duration of treatment is 3-4 months, the therapeutic effect is usually observed after 3 weeks of treatment.
Side effects of
With topical application of the gel, the concentration of metronidazole in the blood is very low, so the risk of developing systemic side effects is low.
Allergic reactions (urticaria, skin rash) hyperemia, peeling, slight dryness and burning of the skin, lacrimation (if the gel is applied close to the eyes) can rarely be observed.
Overdose
No overdose was observed with the recommended doses at the recommended doses.
Storage conditions
Store in a dark place, out of the reach of children, at a temperature not exceeding 30 ° C.
The Expiration of
is 3 years. Do not use after the expiry date stated on the packaging.
Deystvuyuschee substances
metronidazole
pharmacy over-the-counter conditions
Dosage form
Dosage form
gel for external use
Unique Pharmaceutical, India
