Description
Release form
Tablets
Packing
20 pcs.
Pharmacological action
Antibiotic of the broad-spectrum penicillin group, which is destroyed by penicillinase.
Indications
Infectious and inflammatory diseases caused by susceptible microorganisms:
respiratory infections
infections of the genitourinary system
gastrointestinal tract infections
infections of the skin and soft tissues.
Contraindications
Hypersensitivity to the drug’s components Hypersensitivity to other beta-lactam antibiotics, incl. to other penicillins, cephalosporins, carbapenems.
Caution should be used in case of multivalent hypersensitivity to xenobiotics, infectious mononucleosis, lymphocytic leukemia, gastrointestinal diseases in the anamnesis (especially for colitis associated with the use of antibiotics), renal failure, pregnancy and lactation, allergic reactions (including . in the anamnesis).
Ingredients
Active ingredient:
amoxicillin trihydrate
Excipients:
dispersible cellulose – 34.8 mg,
microcrystalline cellulose – 50.5 mg,
crospovidlid 1 mg ppm, mg.4 mg
lemon flavor – 11.1 mg,
saccharin – 13.1 mg,
magnesium stearate – 6 mg.
Side effects of the
From the digestive system: rarely – change in taste, nausea, vomiting, diarrhea, dysbiosis, stomatitis, glossitis in some cases – a moderate increase in the activity of hepatic transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, pseudomembranous and hemorrhagic colitis.
From the urinary system: the development of interstitial nephritis, crystalluria.
From the hemopoietic system: leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia.
From the nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, epileptic seizures.
Allergic reactions: skin reactions, mainly in the form of a specific maculopapular rash, urticaria, skin hyperemia, erythematous rashes, rhinitis, conjunctivitis, erythema multiforme exudative (Stevens-Johnson syndrome), fever, arthralgia, eosinophilia, exfoliative dermatitis, reactions similar to serum sickness, toxic epidermal necrolysis, allergic vasculitis, acute generalized exanthematous pustulosis anotropic, in some cases.
Other: shortness of breath, vaginal candidomycosis, superinfection (especially in patients with chronic diseases or reduced body resistance).
Drug Interactions
Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent acetylsalicylic acid and sulfinpyrazone suppress tubular secretion of penicillins, which leads to an increase in blood T1 / 2 and an increase in blood plasma concentration of T1 / 2.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) exhibit synergism while taking them.
Antagonism is possible when taken with certain bacteriostatic drugs (e.g. chloramphenicol, sulfonamides).
Concomitant use of amoxicillin with estrogen-containing oral contraceptives can reduce the effectiveness of the latter and increase the risk of acyclic bleeding.
Antacids, glucosamine, laxatives, aminoglycosides, food reduce absorption. Ascorbic acid enhances absorption.
Increases the effectiveness of indirect anticoagulants (suppresses the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index) enhances the absorption of digoxin.
The simultaneous use of amoxicillin with allopurinol increases the risk of skin rash.
Overdose
Symptoms: Gastrointestinal dysfunction – nausea, vomiting, diarrhea The result of vomiting and diarrhea can be a violation of the water-electrolyte balance.
Treatment: appoint gastric lavage, activated charcoal, salt laxatives apply measures to maintain water-electrolyte balance, hemodialysis.
Storage conditions
The product should be stored out of reach of children at a temperature not exceeding 25 ° C.
shelf life
5 years
Deystvuyushtee substance
amoxicillin
drugstore conditions
drugstore
Dosage PMA
Astellas Pharma Europe BV, Netherlands
