Description
Release form
coated tablets
Packing
50 pcs.
Pharmacological action
Antimicrobial agent derived from 8-hydroxyquinoline. The mechanism of action is associated with selective inhibition of bacterial DNA synthesis.
Nitroxoline is active against gram-positive bacteria: Staphylococcus spp. (including Staphylococcus aureus), Streptococcus spp. (including beta-hemolytic streptococci, Streptococcus pneumoniae, Enterococcus faecalis), Corynebacterium diphtheriae, Bacillus subtilis of gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Proteus spp., Klebsiella spp., Salmonella, Salmonella, P. salmonella .
Nitroxoline is also active against Mycobacterium tuberculosis, Trichomonas vaginalis, some types of fungi (Candida spp., dermatophytes, molds, some pathogens of deep mycoses).
Indications
Infectious and inflammatory diseases of the urogenital tract (including pyelonephritis, cystitis, urethritis, epididymitis, infected adenoma or prostate carcinoma) caused by nitroxoline-sensitive microorganisms. Prevention of infectious complications during diagnostic and therapeutic procedures (catheterization, cystoscopy) in the postoperative period during surgical interventions on the kidneys and urinary tract.
Contraindications
Impaired renal function accompanied by oligo or anuria, severe liver disease, glucose-6-phosphate dehydrogenase deficiency, cataracts, neuritis, pregnancy, lactation, hypersensitivity to quinoline drugs.
Special instructions
With Nitroxoline, the urine is saffron yellow.
Composition
Active ingredient: nitroxoline 50 mg
Excipients: potato starch, lactose monohydrate, calcium stearate, talc, aerosil, sugar, magnesium carbonate, povidone, titanium dioxide, tartrazine, ponso 4 R, beeswax Vaseline oil
Dosage and administration of
For adults, the dose of nitroxoline is 600-800 mg / day. Multiplicity of admission is 3-4 times / day. with an interval of 6-8 hours. The course of treatment is 10-14 days.
Maximum dose: 1-1.2 g.
For children, the dose of nitroxoline is 10-30 mg / kg / day. in 3-4 doses.
Side effects
From the digestive system: nausea, vomiting, loss of appetite in isolated cases – impaired liver function.
Allergic reactions: skin rash, itching.
From the side of the central nervous system and peripheral nervous system: in isolated cases – ataxia, headache, paresthesia, polyneuropathy with prolonged use, a case of development of optic neuritis is described.
From the cardiovascular system: in isolated cases – tachycardia.
Storage conditions
In the dark place at a temperature of no higher than 20 ° C.
active substance
Nitroxoline
Terms and conditions
prescription
lekarstvennaja form
tablets
