Description
Release form
Parenteral fat emulsion with vitamin E
Packing
Bottle 100 ml.
Pharmacological action
Lipofundin MCT / LCT is a source of energy and essential (polyunsaturated) fatty acids for patients who need parenteral nutrition.
Soybean oil is a refined natural product containing neutral triglycerides predominantly from unsaturated fatty acids. Medium chain triglycerides are a mixture of neutral triglycerides containing mainly caprylic (about 60%) and capric (about 40%) acids.
Medium-chain triglycerides leave the bloodstream faster and oxidize more fully for energy supply than long-chain ones. For this reason, they are preferable for the body as an energy source, especially for some oxidation disorders of long chain triglycerides, such as carnitine deficiency or decreased carnitine-palmitoyltransferase activity.
The polyunsaturated fatty acids, of which only long chain triglycerides are composed, prevent biochemical disturbances in the form of a deficiency of essential fatty acids (DFAs) and correct the clinical manifestations of DFA syndrome.
Phosphatides, which are part of the egg yolk phosphatides, are included in the formation of membrane structures, guarantee their liquid state and biological functions. Glycerol is metabolized in the body as a source of energy, and also used in the synthesis of glycogen and fat.
Indications
Parenteral nutrition, essential fatty acid deficiency syndrome (treatment and prevention).
Contraindications
Hypersensitivity to the drug, lipid metabolism disorders:
pathological hyperlipidemia, fatty nephrosis
acute pancreatitis, accompanied by hyperlipidemia
thromboembolism, ketoacidosis, shock.
Use during pregnancy and lactation
The safety of the drug during pregnancy has not been proven.
Benefits and risk should be weighed before prescribing the drug to pregnant women. Use is not recommended especially in the first trimester of pregnancy. Breastfeeding is not recommended when using the drug.
Special instructions
Vials must not be frozen if accidentally frozen, the vials should be discarded.
Unused solution is not stored for future use. No filters are used for infusion of fat emulsions.
Composition
Active ingredients:
soybean oil,
medium chain triglycerides (MCT),
egg yolk phosphatides,
glycerol, tocopherol,
water for injection up to 1000.0 ml.
Side effects
Acute reactions: shortness of breath, cyanosis, hyperlipidemia, hypercoagulation, nausea, vomiting, headache, facial flushing, hyperthermia, increased sweating, chills, drowsiness, pain in the sternum and lower back.
Late reactions: hepatomegaly, cholestatic jaundice, transient increase in the activity of hepatic transaminases, thrombocytopenia, leukopenia, splenomegaly, hyperhydration syndrome.
Accumulation of brown pigment (the so-called “in / in fat pigment”) in the reticuloendothelial system.
Overdose
Symptoms: hypervolemia, shortness of breath, cyanosis, pulmonary edema, hyperlipidemia, hypercoagulation.
Treatment: symptomatic with mandatory termination of infusion.
Storage conditions
Protect from freezing. Vials should not be used during freezing.
Store at a temperature not exceeding +25 ° C
Term hodnosty
2 years
active substance
fat emulsions for parenteral nutrition
conditions granted through pharmacies
In retseptu
lekarstvennaja form
Ñmulsyya for infusions
