Description
Description
Transparent or translucent gel from light yellow to yellow, allowed to light yellow to yellow. It has a faint characteristic odor.
Pharmacological action
Thrombless ® Plus is a combination drug. Heparin sodium is a direct-acting anticoagulant, has anti-inflammatory, anti-proliferative, decongestant, and analgesic effects. Reduces platelet aggregation, binds to antithrombin III, preventing the passage of prothrombin to thrombin. Inhibits the activity of thrombin. Reduces the activity of hyaluronidase, increases the fibrinolytic properties of blood. It improves microcirculation and activates tissue metabolism, due to this it accelerates the resorption of hematomas and blood clots, ultimately restores vein patency, clinically this is accompanied by a pronounced analgesic and anti-inflammatory effect. Dexpanthenol – provitamin B5 – in the skin turns into pantothenic acid, which is part of coenzyme A, which is involved in acetylation, carbohydrate and fat metabolism, stimulates skin regeneration, normalizes cellular metabolism, and increases the strength of collagen fibers. It has a regenerative, vitamin, metabolic and anti-inflammatory effect, improves heparin absorption. Troxerutin – a flavonoid (a derivative of rutin), has P-vitamin activity, has a venotonic effect, angioprotective, decongestant, antioxidant and anti-inflammatory effects. It participates in redox processes, blocks hyaluronidase, stabilizes cell wall membranes hyaluronic acid and reduces capillary permeability and fragility, and increases their tone. It increases the density of the vascular wall, reduces the exudation of the liquid part of the plasma and the diapedesis of blood cells. Reduces inflammation in the vascular wall, limiting platelet adhesion to its surface. Benzocaine is a local anesthetic for surface anesthesia. It reduces the permeability of the cell membrane for sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane, and blocks the conduction of nerve impulses. Prevents the occurrence of pain impulses in the endings of sensory nerves and their passage through nerve fibers. Benzocaine dilates the superficial blood vessels, promoting the absorption of heparin.
Indications
Chronic venous insufficiency, accompanied by symptoms such as swelling, pain, feeling of heaviness in the legs, feeling “full”, tired legs, spider veins and nets, cramps, paresthesias (numbness, tingling, crawling crawls).
Varicose disease of the lower extremities.
Migrating phlebitis, thrombophlebitis.
Subcutaneous hematomas, localized edema and aseptic infiltrates, including on the face.
Injuries and bruises of joints, tendons, muscle tissue.
Complications arising from surgical operations on the veins.
Contraindications
Hypersensitivity to the components of the drug, children (up to 2 years). Precautions Hepatic and / or renal failure, alcoholism, blood diseases, tumors, metabolic diseases, vascular pathology of the limbs.
Use during pregnancy and lactation
Use of the drug Trombless Plus during pregnancy and lactation is contraindicated.
Special instructions
A decrease in the severity of clinical manifestations is usually observed in the early days of treatment. In the case of irregular treatment or premature termination of it, there is a risk of a renewed infection. In the absence of signs of improvement after 1-2 weeks of therapy, the diagnosis should be verified. The cream is intended for external use only. Avoid contact with the mucous membrane of the eyes, nose, and mouth. If the drug enters the mucous membrane, rinse with water and consult a doctor if necessary.
Composition
1 g of gel contains: active ingredients: sodium heparin – 1000 IU (8.33 mg with sodium heparin activity 120 IU / mg), troxerutin – 20.0 mg, dexpanthenol – 100.0 mg, benzocaine – 1.0 mg
excipients: ethanol, methyl parahydroxybenzoate , trolamine, carbomer, glycerol, water.
Dosage and administration
The drug is applied to the skin once or twice a day. Before applying the cream, it is necessary to clean and dry the affected areas. The cream is applied in a thin layer on the affected skin and rubbed lightly. To increase the effectiveness of treatment, the use of occlusive dressings is possible. For infections accompanied by diaper rash (under the mammary glands, in the interdigital spaces, between the buttocks, in the inguinal region), the place of application of the cream can be covered with gauze, especially at night. The average duration of treatment: Dermatomycosis of the trunk, legs: 1 week 1 time per day. Dermatomycosis of the feet: 1 week 1 time per day. Skin candidiasis: 1 or 2 times a day for 1-2 weeks. Multi-colored lichen: 1 or 2 times a day for 2 weeks.
Side effects
In rare cases, there was redness, itching or burning sensation at the place of application of the cream, however, these phenomena rarely led to the need to stop treatment. The above symptoms should be distinguished from allergic reactions, for example, urticaria, which rarely occur, however, when they appear, it is necessary to stop treatment.
Storage conditions
At a temperature not exceeding 20 ° C. Keep out of the reach of children.
Expiration
2 years. Do not use the drug after the expiration date indicated on the package.
Active ingredient
Sodium heparin, Dexpanthenol, Troxerutin
Terms and conditions
without prescription
Dosage form
gel for external use
Appointment
Adult, Beremenn m in naznacheniyu Vracha
Nizhpharm, Russia
