Description
Release form
Set of film-coated tablets, 0.1 mg + 0.02 mg and 0.01 mg.
Packing
2 blisters for 28 tablets of levonorgestrel and ethinyl estradiol and 1 blister for 28 tablets of levonorgestrel and ethinyl estradiol and 7 tablets of ethinyl estradiol, tight-fitting with a cardboard blister holder together with an adsorbent in a foil bag.
1 foil bag along with instructions for use and a card with stickers in a cardboard box.
Pharmacological action
Modell Lieber – combined oral estrogen-progestogen contraceptive for continuous long-term use for 91 days. The contraceptive effect of the drug is due to the complementary mechanisms of the active substances, the most important of which include suppressing ovulation, increasing the viscosity of the secretion of the cervix, which complicates the penetration of sperm into the uterine cavity, and changes in the endometrium that prevent the implantation of a fertilized egg.
When using the Model Liber drug, the amount of menstrual bleeding decreases to four per year. In the last 7 days of long-term use of the drug (on days 85-91), against the background of using 10 μg of ethinyl estradiol instead of placebo, there is an increase in suppression of the follicular apparatus of the ovaries and a decrease in the risk of missing ovulation. Menstrual-like bleeding associated with drug withdrawal occurs due to the fact that there is no progestin effect on the endometrium, but in women there is a residual suppression of the hypotolamic-pituitary system due to the administration of a small dose of ethinyl estradiol to control the functional activity of the ovaries.
Indications
Oral contraception.
Contraindications
thrombosis (venous and arterial) and history of thromboembolism (including deep vein thrombosis, pulmonary thromboembolism, myocardial infarction, cerebrovascular disorders) previous thrombotic conditions ischemic attacks, angina pectoris) currently or in the history of
multiple or severe risk factors for venous or arterial thrombosis
hereditary or acquired predisposition to venous or arterial thrombosis: resistance ntnost to activated protein C, hyperhomocysteinemia, antithrombin III deficiency, protein C deficiency, protein deficit S, the presence of antibodies to phospholipids (antibodies to cardiolipin, lupus anticoagulant)
migraine with focal neurological symptoms at present or in a history of
uncontrolled arterial hypertension
diabetes mellitus with diabetic angiopathy
pancreatitis with severe liver failure or liver disease in the present a)
liver tumors (benign or malignant) currently or in a history of
severe
dyslipoproteinemia Revealed malignant hormone-dependent diseases (including genitals or mammary glands) or suspected
vaginal bleeding of unknown origin
pregnancy or suspected
breastfeeding period
age under 18 years (due to the lack of data on the efficacy and safety of the drug in adolescent girls under 18 )
simultaneous use with perforated St. John’s wort preparations hypersensitivity to any of the components of the
preparation galactose intolerance, lactase deficiency or glucose-galactose malabso rbiya, tk. the composition of the drug includes lactose
postmenopausal period.
Dosage and administration
The drug Model Liber is taken orally continuously for 91 days, 1 tablet per day at the same time in the order indicated on the package (blister).
To achieve the greatest contraceptive effect, the drug should be taken in accordance with the recommendations and at intervals not exceeding 24 hours.
Storage conditions
Store at a temperature not exceeding 25 ° C, in a place protected from light and moisture. Keep out of the reach of children.
Active ingredient
Levonorgestrel, Ethinyl estradiol Ethinyl estradiol [kit]
Pharmacy terms of sale
Prescription
lekarstvennaja form
tablets
Appointment
for women, Vzrosl m on purpose doctor, for women detorodnoho age
Indications
For contraception
Teva Pharmaceutical Enterprise Co., Ltd., Israel
