Description
Release form
Tablets
packing
30 pcs
Pharmacological action
The exact mechanism of action of the allergen during allergen specific immunotherapy (ASIT) is not fully understood. The following biological changes are proven: the appearance of specific antibodies (IgG4), playing the role of “blocking antibodies” a decrease in the level of specific IgE in plasma for a long period of time, a decrease in the reactivity of cells involved in an allergic reaction, an increase in the activity of interaction between Th2 and Th1 and even Th0 T-lymphocytes, leading to a positive change in cytokine production (decrease in IL-4 and increase interferon gamma), regulating the production of IgE. In addition, ASIT induces an immune response, which allows you to maintain immunobiological memory for a long period. The effectiveness of ASIT is higher when treatment is started in the early stages of the disease.
Indications
Allergen specific immunotherapy (ASIT) for patients with type 1 allergic reaction (IgE mediated), manifested in the form of rhinitis or rhinoconjunctivitis, which are hypersensitive to pollen from meadow ladders (hedgehog, common spikelet, common chaff, meadow bluegrass, meadow timothy), confirmed by positive results from skin testing and / or an increased content of specific IgE. Immunotherapy can be carried out for adults and children from 5 years of age.
Contraindications
Hypersensitivity to one of the excipients
beta-blocker therapy
uncontrolled or severe bronchial asthma (forced expiratory volume less than 70%)
severe immunodeficiencies and ulcerous diseases ulcerous diseases lichen planus, ulceration, mycosis)
hereditary galactose intolerance, Lapp lactase deficiency, impaired glucose absorption and galactoses.
Special instructions
For surgical procedures in the rh cavity (including removal of tubes), therapy should be interrupted until it is completely cured (at least for 7 days). In the case of severe allergic reactions, the doctor may recommend taking epinephrine. It should be borne in mind that in patients taking tricyclic antidepressants, monoamine oxidase inhibitors, the risk of side effects on its administration increases up to death. There is no clinical experience with simultaneous vaccination and drug treatment. Vaccination can be carried out only after consulting a doctor. The drug does not affect the ability to drive vehicles and mechanisms.
Composition
Active substance: allergen extract from the mixture grass pollen (team hedgehog, common spikelet, chaff, perennial chaff, meadow bluegrass, timothy meadow) in equal proportions 100 IR and 300 IR
Excipients: microcrystalline cellulose – 12.5 mg, croscarmellose sodium – 2.5 mg, silicon dioxide colloid – 0.5 mg, magnesium stearate – 0.7 mg, lactose monohydrate – d 100 mg
Dosage and administration of
Treatment with the drug should be carried out by an allergist. If the drug is used in pediatric practice, the doctor must have appropriate experience in treating children. It is recommended that you take the first pill under the supervision of a doctor to monitor the patient for 30 minutes. Treatment should be started 4 months before the expected flowering season, continued throughout the dusting season and stopped with its end. The drug is recommended to be taken in the morning on an empty stomach. The tablet should be placed under the tongue and kept until completely dissolved (for at least 1 minute), then swallow. Breaks in taking the drug should be avoided. Do not increase the dose after skipping the drug. If the pass in taking the drug is less than 7 days, it is recommended to resume taking the drug in the same dose at which the treatment was interrupted, and then follow the recommended regimen. With a long pass (more than 7 days), you should consult your doctor.
Side effects of the
From the immune system: allergic reactions.
From the side of the central nervous system and peripheral nervous system: headache, dizziness, change in taste, paresthesia.
From the side of the organ of vision: conjunctivitis, hyperemia.
On the part of the hearing organ: itchy ears, stuffy ear.
From the respiratory system: sore throat, difficulty breathing, swelling, rhinitis symptoms, sore throat, cough, suffocation, dysphonia.
From the gastrointestinal tract: itching, swelling, inflammation, numbness, tingling in the oral cavity, increased salivation, dry mouth, lips, vesicular eruptions in the mouth, lips, glossodynia, gastrointestinal upsets, inflammation in the gastrointestinal tract intestinal tract.
From the skin and subcutaneous tissues: facial swelling, itching, urticaria, angioedema, eczema.
General disorders: fatigue, anxiety.
Storage conditions
Keep out of the reach of children, at a temperature not higher than 25 C.
active substance
Allergens grass pollen
Terms and conditions otpuska IZ pharmacy prescription
lekarstvennaja form
tablets
