Description
Release form
Dispersible tablets.
Packing
20 pcs.
Pharmacological action
Broad-spectrum penicillin antibiotic that is destroyed by penicillinase.
Indications
Infectious and inflammatory diseases, caused by microorganisms sensitive to the drug:
– respiratory infections
– urinary tract infections
– gastrointestinal tract infections
– infections of the skin and soft tissues.
Contraindications
– hypersensitivity to the components of the drug
– hypersensitivity to other beta-lactam antibiotics, including to other penicillins, cephalosporins, carbapenems.
Caution should be used in case of multivalent hypersensitivity to xenobiotics, infectious mononucleosis, lymphocytic leukemia, gastrointestinal diseases in the anamnesis (especially for colitis associated with the use of antibiotics), renal failure, pregnancy and lactation, allergic reactions (including . in the anamnesis).
Composition of
Amoxicillin trihydrate 1.1655 g, which corresponds to the content of amoxicillin 1 g
Excipients:
cellulose dispersible – 34.8 m mg,
mandarin flavoring – 9.1 mg,
lemon flavoring – 11.1 mg,
saccharin – 13.1 mg,
magnesium stearate – 6 mg.
Side effects of the
From the digestive system: rarely – a change in taste, nausea, vomiting, diarrhea, dysbiosis, stomatitis, glossitis in some cases – a moderate increase in the activity of hepatic transaminases, cholestatic jaundice, liver cholestasis, acute pseudolithic hepatitis and hepatitis, hepatitis .
From the urinary system: the development of interstitial nephritis, crystalluria.
From the hemopoietic system: leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia.
From the side of the nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, epileptic seizures.
Allergic reactions: skin reactions, mainly in the form of a specific maculopapular rash, urticaria, skin hyperemia, erythematous rashes, rhinitis, conjunctivitis, erythema multiforme exudative (Stevens-Johnson syndrome), fever, arthralgia, eosinosis, eosin similar to serum sickness, toxic epidermal necrolysis, allergic vasculitis, acute generalized exanthematous pustulosis in some cases – anaphylactic shock, angioedema.
Other: shortness of breath, vaginal candidomycosis, superinfection (especially in patients with chronic diseases or reduced body resistance).
Drug Interactions
Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent acetylsalicylic acid and sulfinpyrazone suppress tubular secretion of penicillins, which leads to an increase in blood T1 / 2 and an increase in plasma concentration of T1 / 2.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) exhibit synergism while taking them.
Antagonism is possible when taken with certain bacteriostatic drugs (eg, chloramphenicol, sulfonamides).
Concomitant use of amoxicillin with estrogen-containing oral contraceptives can reduce the effectiveness of the latter and increase the risk of acyclic bleeding.
Antacids, glucosamine, laxatives, aminoglycosides, food reduce absorption. Ascorbic acid enhances absorption.
Increases the effectiveness of indirect anticoagulants (suppresses the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index) enhances the absorption of digoxin.
The simultaneous use of amoxicillin with allopurinol increases the risk of skin rash.
overdose
Symptoms:
Gastrointestinal dysfunction – nausea, vomiting, diarrhea Vomiting and diarrhea can be caused by water and electrolyte balance.
Treatment:
prescribe gastric lavage, activated charcoal, salt laxatives apply measures to maintain water-electrolyte balance, hemodialysis.
Storage conditions
The product should be stored out of reach of children at a temperature not exceeding 25 ° C.
Shelf life
5 years.
Deystvuyushtee substance
amoxicillin
Terms and conditions otpuska IZ drugstore
prescription
dosage form
tablets soluble
Prescribing
Prescribing
Prescribing to nursing mothers, Adults as prescribed by the doctor, Children as prescribed by the doctor, Pregnant as prescribed by the doctor
Astellas Pharma Europe BV, Netherlands
