Description
Release form
Capsules
Packaging
60 pcs
Pharmacological action of
Acetyl-L-carnitine (ALA), a natural biologically active substance, under physiological conditions, present in the body in various organs and tissues, including the central nervous system, is involved in the metabolism of fatty acids and carbohydrates.
The pharmacological and biological effects of ALA are largely due to the metabolic effects of L-carnitine and the acetyl group included in its composition. Acetyl-L-carnitine (ALA), a biologically active form of L-carnitine, a key substance in the process of fat catabolism and energy formation in the body. ALA is synthesized in brain tissue, liver and kidneys from L-carnitine with the participation of the carnitine acetyltransferase enzyme.
Since ALA supplies activated acetate directly to the mitochondrial matrix to form acetyl-CoA, which is involved in the tricarboxylic acid cycle, without additional energy consumption, it is an easily accessible substrate for triggering volatile metabolic processes in the mitochondria. Due to the full energy supply of the body with less oxygen consumption by tissues, ALA protects the brain tissue from ischemia.
Due to its structural similarity with acetylcholine, ALA has a cholinomimetic effect and also exhibits neuroprotective properties. It increases the cellular concentration of aspartic and glutamic acid, as well as taurine, with prolonged use increases the density of N-methyl-D-aspartate receptors in the hippocampus, cortex and striatum and prevents their density from decreasing under aging conditions. ALA enhances the effects of serotonin and also protects brain cells from the neurotoxic effects of ammonia and glutamate.
The results of experimental studies have shown that ALA has antiamnestic activity, the ability to improve learning processes, indicators of non-associative memory, have a positive effect on mnemonic functions in an experimental model of Alzheimer’s disease, without causing side effects of a sedative and muscle relaxant nature.
ALA increases energy production, being an easily accessible substrate for starting energy-dependent metabolic processes in the mitochondria. Stimulates the synthesis of proteins and phospholipids for building membranes, improves regeneration processes.
In pathology, it has a neuroprotective effect, especially in relation to neurons and their organelles (mitochondria), as well as a neurotrophic effect due to modulation of the activity of nerve growth factor (NGF). It has antioxidant and membrane stabilizing effects. ALA can accelerate the regeneration of nerve cells in traumatic and endocrine injuries of peripheral nerves in experimental models of polyneuropathy in diabetes.
ALA has a noticeable effect on slowing down the aging process by enhancing the transport of fatty acids in the mitochondria and maintaining their work at the level of a young body. ALA can accelerate the regeneration of nerve cells in traumatic and endocrine injuries of peripheral nerves in experimental models of diabetes.
Contraindications
Individual hypersensitivity to the drug Karnitsetin
Age up to 18 years (efficacy and safety have not been established).
Use during pregnancy and lactation
No specific studies have been carried out on the possibility of use during pregnancy and breastfeeding if the intended benefit to the mother outweighs the risk to the fetus.
Breastfeeding should be discontinued during treatment.
Composition of
Acetylcarnitine hydrochloride (carniquetin) 0.295 g
Excipients:
microcrystalline cellulose (MCC) srdl 0.34 g
Hard gelatine capsules:
capsule composition – gelatin
glycerol (glycerin)
nipagin (methyl parahydroxybenzoate)
nipazole (propyl parahydroxybenzoate)
sodium lauryl sulfate
purified water,
titanium.
Dosage and Administration
Inside. A single dose for adults is usually 14 caps., A daily dose of 612 caps.
The course of treatment is 14 months.
Side effects
Allergic reactions possible nausea, heartburn.
Drug Interactions
No cases of drug interactions noted.
Overdose
No cases of overdose.
Storage Conditions
In a dry, dark place at a temperature not exceeding 25 ° C.
Expiration
2 years. Do not use after the expiry date.
active substance
Acetylcarnitine
Conditions of release of drugstores
15 TMP
capsule
Pik-Pharma, Russia
