Description
Pharmacological action of
As a result, the synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. Consider, that ASA has other mechanisms for suppressing platelet aggregation, which expands its scope in various vascular diseases.
ASA also has anti-inflammatory, analgesic, antipyretic effect. The anti-inflammatory effect is associated with a decrease in blood flow due to inhibition of prostaglandin E2 synthesis. Magnesium hydroxide, which is part of the drug Phasostabil, has an antacid effect and protects the mucous membrane of the gastrointestinal tract from the effects of ASA.
Indications
– Primary prophylaxis of cardiovascular diseases such as thrombosis and acute heart failure in the presence of risk factors (eg, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age).
– Prevention of recurrent myocardial infarction and blood vessel thrombosis.
– Prevention of thromboembolism after vascular surgery (coronary artery bypass grafting, percutaneous transluminal coronary angioplasty).
– Unstable angina pectoris
Contraindications
– Hypersensitivity to ASA, drug excipients and other non-steroidal anti-inflammatory drugs (NSAIDs)
– Cerebral hemorrhage
– Bleeding tendency (vitamin K deficiency, thrombocytopenia class III, hemorrhagic disease) -IV according to NYHA classification
– Bronchial asthma induced by salicylates and NSAIDs
– Complete or incomplete combination of recurrent asthma lipose of the nose and paranasal sinuses, and intolerance to ASA or other NSAIDs, including cyclooxygenase-2 inhibitors (COX-2) (including a history)
– Erosive-ulcerative lesion of the gastrointestinal tract (in the acute phase)
– Gastrointestinal bleeding
– Severe renal failure (creatine clearance) less 30 ml / min.)
– Liver failure (Child-Pugh classification B and C)
– Pregnancy (I and III trimesters),
breastfeeding period –
glucose-6-phosphate dehydrogenase deficiency – Concomitant use with methotrexate (more 15 mg per week)
– Children under 18 years of age.
Composition
1 tablet contains:
active substance:
acetylsalicylic acid – 75.00 mg
magnesium hydroxide – 15.20 mg,
acetylsalicylic acid – 150.00 mg
magnesium hydroxide – 30.39 mg.
Dosage and administration
Inside, film-coated tablets of the drug Phasostabil are swallowed whole with water. Phasostabil is intended for long-term treatment. The duration of treatment is determined by the doctor.
– Primary prevention of cardiovascular diseases such as thrombosis and acute heart failure in the presence of risk factors (for example, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age) 1 tablet of the drug Phasostabil, containing ASA in a dose of 150 mg on the first day, then 1 tablet containing ASA in a dose of 75 mg once a day.
– Prevention of recurrent myocardial infarction and blood vessel thrombosis 1 tablet of the drug Phasostabil containing ASA in a dose of 75-150 mg 1 time per day.
– Prevention of thromboembolism after vascular surgery (coronary artery bypass grafting, percutaneous transluminal coronary angioplasty) 1 tablet of the drug Phazostabil containing ASA in a dose of 75 – 150 mg once a day.
– Unstable angina pectoris 1 tablet of the drug Fazostabil containing ASA in a dose of 75-150 mg once a day. When skipping the next dose of the drug Fazostabil, it is necessary to take the missed dose of the drug as soon as the patient remembers this. To avoid doubling the dose, you should not take a missed tablet, if the next dose is approaching.
Peculiarities of action during the first administration or withdrawal of the drug were not observed.
active substance
Acetylsalicylic acid, [magnesium hydroxide]
Terms of delivery from pharmacies
Over-the-counter
