Description
Release form
capsules
Packing
2 pcs.
Pharmacological action
Azitrox ® is a broad-spectrum antibiotic. It is the first representative of a new subgroup of macrolide antibiotics – azalides. When creating high concentrations of inflammation in the focus, it has a bactericidal effect.
Gram-positive cocci are sensitive to azithromycin: Streptococcus pneumoniae, St. pyogenes, St. agalactiae, streptococci of CF and G groups, Staphylococcus aureus, St. Viridans gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, B. parapertussis, Legionella pneumophila, H. ducrei, Campylobacter jejuni, Neisseria gonorrhoeae, and Gardnerella vaginalis are some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp, as well as Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealylamus burelilamidum urealylamum Azithromycin is inactive against gram-positive bacteria resistant to erythromycin.
Azithromycin persists in bactericidal concentrations in the focus of inflammation for 5-7 days after the last dose, which allowed the development of short (3-day and 5-day) courses of treatment.
Indications
– Infectious and inflammatory diseases caused by drug-sensitive microorganisms:
– Infections of the upper respiratory tract and ENT organs (tonsillitis, sinusitis, tonsillitis, otitis media)
– Scarlet fever
– Lower respiratory tract infections (bacterial and atypical pneumonia, bronchitis)
– Infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses)
– Infections of urogenital tract / or cerebral)
– Lyme disease (borreliosis), for the treatment of the initial stage (erithema migrans)
– A disease of the stomach and duodenum associated with Helicobacter pylori.
Special instructions
Not recommended for use in patients with impaired liver function.
Use with caution in cases of impaired renal function.
Azithromycin should be taken at least 1 hour before or 2 hours after a meal or antacids.
Composition
1 capsule contains azithromycin 0.5 g
excipients:
lactose anhydrous or mannitol, srdlp
sodium lauryl sulfate
Dosage and administration of
Azitrox® should be taken 1 hour before a meal or 2 hours after a meal. The drug is taken 1 time / day.
For infections of the upper and lower respiratory tract, infections of the skin and soft tissues, 500 mg / day is prescribed for 3 days (course dose – 1.5 g).
In case of uncomplicated urethritis and / or cerebellum, 1 g is prescribed once (4 capsules, 250 mg each).
In Lyme disease (borreliosis), 1 g (4 caps.) is prescribed for the treatment of the initial stage (erithema migrans). 250 mg) on ??the 1st day and 500 mg daily from the 2nd to the 5th day (course dose – 3 g).
In diseases of the stomach and duodenum associated with HelicobacterPylori, 1 g (4 capsules of 250 mg) per day is prescribed for 3 days as part of combination therapy.
If you miss one dose of the drug, you should take the missed dose as soon as possible, and the next with a 24-hour interval.
Side effects of the
From the digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient increase in the activity of liver enzymes rarely – cholestatic jaundice.
Allergic reactions: rarely – skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Dermatological reactions: rarely – photosensitivity.
From the side of the central nervous system: dizziness, headache rarely – drowsiness, weakness.
From the hemopoietic system: rarely – leukopenia, neutropenia, thrombocytopenia.
From the cardiovascular system: rarely – chest pain.
From the genitourinary system: vaginitis rarely – candidiasis, nephritis, increased residual urea nitrogen.
Other: rarely – hyperglycemia, arthralgia.
Drug Interactions
When used together with ergot alkaloids, the risk of ergotism cannot be ruled out.
With the simultaneous use of azithromycin with warfarin, cases of increased effects of the latter have been described.
With the simultaneous use of digoxin or digitoxin with azithromycin, a significant increase in the concentration of cardiac glycosides in blood plasma and a risk of developing glycoside intoxication are possible.
With simultaneous use with disopyramide, a case of ventricular fibrillation has been described.
With simultaneous use with lovastatin, cases of rhabdomyolysis have been described.
When used concomitantly with rifabutin, the risk of developing neutropenia and leukopenia is increased.
With simultaneous use, cyclosporine metabolism is disrupted, which increases the risk of adverse and toxic reactions caused by cyclosporin.
Storage conditions
In a dry, dark place at room temperature.
Keep out of the reach of children.
Expiration
2 years.
Deystvuyuschee substances
Azithromycin
pharmacy terms of prescription
Form of Treatment
kapsul
Appointment by
Children by doctor’s appointment, Adult, Children over 12 years by p9rof467 doctor’s appointment, Children over 12 years old, Adult prescribers
indications
bronchitis, infectious diseases, pharyngitis, Skin infections, Tonsillitis, Sore throat, Sinusitis, Otitis media, Inflammation of the lungs, Respiratory tract infections, Urethritis, Cystitis
Possible product names
AZITROX 0.5 N2 CAPS
Azitrox 500mg Caps. X2 (R)
Azitrox caps 500mg N2 packs per pack ind pack
Azitrox caps 500mg N2 packs per pack ind packs *
Azitroks caps 500mg x 2
Pharmstandard-Leksredstva, Russia
