Description
Pharmacological action of
Pharmacotherapeutic group:
non-steroidal anti-inflammatory drug
ATC code: Ñ 01AD02
Pharmacological properties of
Pharmacodynamics
Benzidamine is a non-steroidal anti-inflammatory drug. It has an anti-inflammatory and local anesthetic effect, has an antiseptic effect against a wide range of microorganisms. The mechanism of action of the drug is associated with stabilization of cell membranes and inhibition of prostaglandin synthesis.
Benzidamine has an antibacterial and specific antimicrobial effect due to the rapid penetration of microorganisms through the membranes, followed by damage to cellular structures, metabolic processes and cell lysosomes.
Has antifungal activity against Candida albicans. It causes structural modifications of the cell wall of fungi and their metabolic chains, thus inhibiting their reproduction, which was the basis for the use of benzidamine in inflammatory processes in the oral cavity, including infectious etiology.
Pharmacokinetics
When applied topically, the drug is well absorbed through the mucous membranes and penetrates into inflamed tissues, is found in plasma in an amount insufficient to produce systemic effects.
Excretion of the drug occurs mainly by the kidneys, in the form of inactive metabolites or conjugation products.
Indications
Symptomatic pain therapy for inflammatory diseases of the oral cavity and ENT organs (of various etiologies):
-gingivitis, glossitis, stomatitis (including after radiation and chemotherapy)
-pharyngitis, laryngitis, mucosal tonsillitis oral membranes (as part of combination therapy)
-calculous inflammation of the salivary glands
-after surgical interventions and injuries (tonsillectomy, jaw fractures)
-after treatment and tooth extraction
-periodontosis
Infectious and inflammatory disorders requiring systemic treatment Tantum ® Verde should be used as part of combination therapy.
Contraindications
Hypersensitivity to benzydamine or other components of the
drug fructose intolerance
children under 6 years old
phenylketonuria
Caution
Hypersensitivity to acetylsalicylic acid or other.
Use during pregnancy and lactation
The drug Tantum ® Verde should not be used during pregnancy and during breastfeeding.
Special instructions
Hypersensitivity reactions may occur with Tantum ® Verde. In this case, it is recommended to discontinue treatment and consult a doctor to prescribe appropriate therapy.
In a limited number of patients, the presence of ulcers in the throat and oral cavity may indicate a more serious pathology. If symptoms persist for more than 3 days, consult a doctor.
The use of Tantum ® Verde is not recommended in patients with hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.
The drug Tantum ® Verde should be used with caution in patients with a history of bronchial asthma due to the possibility of developing bronchospasm in patients with the drug.
The drug contains isomaltose and, therefore, is not recommended in patients with hereditary fructose intolerance.
The use of the drug in children is possible only under the supervision of adults to avoid swallowing the pill.
Impact on the ability to drive vehicles, mechanisms
Does not affect the ability to drive vehicles and work with mechanisms.
Composition of
For one tablet for resorption:
The active ingredient of
-benzidamine hydrochloride is 3 mg.
Auxiliary ingredients:
isomaltose 3183 mg,
racemolol 4 mg,
aspartame 3.5 mg,
citric acid,
monohydrate 2 mg,
flavor peppermint 5 mg,
flavor lemon yellow 10 mg, lemon lemon red 10 mg ) 0.035 mg,
dye Indigo Carmine (E132) 0.015 mg.
Dosage and Administration
Locally, after meals. Adults (including elderly patients) and children over 6 years of age: 1 tablet for resorption 3 times a day. Keep the tablets in your mouth until completely dissolved. Do not swallow. Do not chew. Do not exceed recommended dose. Children from 6 to 12 years of age use the drug under the supervision of an adult.
Duration of treatment should not exceed 7 days. If after treatment within 7 days there is no improvement or new symptoms appear, it is necessary to consult a doctor.
Use the drug only according to the method of use and at the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.
Side effects
Classification of the incidence of side effects of the World Health Organization (WHO): very often -? 1/10
often – from? 1/100 to <1/10 infrequently – from? 1/1000 to <1/100 rarely – from? 1/10000 to <1/1000 very rare – <1/10000 frequency is unknown – cannot be estimated based on available data. In each group, unwanted effects are presented in decreasing order of severity. Local reactions: rarely – dry mouth, burning sensation in the oral cavity frequency is unknown – a feeling of numbness in the oral cavity. Allergic reactions: infrequently – photosensitivity rarely – hypersensitivity reactions. skin rash, itching very rarely – angioedema, laryngospasm frequency unknown – anaphylactic reactions. If any of the side effects indicated in the instructions are aggravated, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor. Drug Interactions No interaction studies with other drugs have been conducted. Overdose of No overdose of Tantum ® Verde has been reported at this time. Symptoms: when using the drug in accordance with the instructions for use, an overdose is unlikely. If the drug is accidentally swallowed, the following symptoms are possible: vomiting, abdominal cramps, anxiety, fear, hallucinations, cramps, ataxia, fever, tachycardia, respiratory depression. Treatment: symptomatic cleanse the stomach by inducing vomiting or rinse the stomach using a gastric tube (under the supervision of a physician) to provide medical supervision, supportive therapy and necessary hydration. The antidote is not known. Storage conditions At a temperature not exceeding 25 ° C, in a dark place. Keep out of the reach of children. The Expiration of is 4 years. Deystvuyuschee substances benzydamine over-the-counter pharmacies Form of Treatment tablets dlya rassas vaniya
