Description
Pharmacological action of
Carprofen inhibits the enzyme cyclooxygenase in the arachidonic acid cycle. In this case, the drug mainly affects cyclooxygenase-II, which is produced in response to inflammation. As a result, the synthesis of prostaglandins is blocked. In therapeutic doses, carprofen has a much weaker effect on cyclooxygenase-I, and therefore does not significantly affect the synthesis of protective prostaglandins, a deficiency of which in the body can cause impaired renal function (slowing down renal blood flow), platelet aggregation, increased secretion of the glands of the stomach and intestines, and violation water-salt balance, cardiac activity and other functional disorders. The drug has anti-bradykinin activity, inhibiting the perception of pain at the level of the central parts of the brain and spinal cord. Carprofen is rapidly absorbed from the gastrointestinal tract, and its concentration reaches a peak in blood plasma 1 to 3 hours after oral administration. The elimination half-life is about 10 hours. Carprofen is more than 99% bound to plasma proteins and metabolized in the liver, excreted in feces (about 80%) and urine. Rikarfa meat-flavored tablets, according to the degree of impact on the body of warm-blooded animals, are classified as moderately hazardous substances.
Indications
Assign to dogs for inflammatory and pain syndromes arising from acute and chronic diseases of the musculoskeletal system, as well as during postoperative rehabilitation of the animal.
Contraindications
Increased individual sensitivity of animals to carprofen. The drug should not be prescribed to pregnant and lactating females, puppies younger than 6 weeks of age. The drug is not recommended at the same time as other non-steroidal anti-inflammatory drugs, glucocorticoids, diuretics and anticoagulants. If it is necessary to prescribe the above medicines to the animal, their use can be carried out no earlier than 24 hours after the cancellation of Rikarf, meat-flavored tablets or 24 hours before they are taken.
Special instructions
The drug is used with caution in animals with diseases of the heart, kidneys and liver.
Ingredients
Ricarda meat-flavored tablets is a non-steroidal anti-inflammatory and analgesic drug for dogs (international nonproprietary name: carprofen). The drug as an active ingredient in one tablet contains 20 mg of carprofen and auxiliary components: lactose monohydrate, corn starch, red iron oxide, black iron oxide, K30 polyvidone, sodium starch glycolate, colloidal silicon anhydride, talc, magnesium stearate and odor and taste flavor meat 10022.
Dosage and administration
For dogs, the drug is administered orally, individually for 7 days, twice a day at a dose of 4 mg carprofen per 1 kg of animal body weight per day or at the rate of 1 tablet of the drug 20 mg per 5 kg of animal body weight, respectively. After 7 days of treatment, subject to an improvement in the clinical condition of the animal and persistent positive dynamics, the dose of the drug can be halved. The duration of the course is determined by the attending veterinarian individually, depending on the condition of the animal and the nature of the pathological process.
Side effects
In rare cases, when the drug is used in animals, irritation of the gastric mucosa and vomiting are noted. In these cases, the use of the drug is stopped and, if necessary, the veterinarian prescribes symptomatic and desensitizing therapy to the animal.
Storage conditions
In a dry place, protected from direct sunlight and out of the reach of children and animals. Separately from food and feed in the manufacturer s packaging at a temperature of 0 to 25 ° C.
Shelf life
3 years.
Active ingredient
Karprofen
dosage form
tablets
