Clomipramine – Anafranil SR tablets 75 mg 10 pcs

$21.00

Description

Release form

sustained-release tablets, film-coated

Packing

10 pcs.

Pharmacological action of

Anafranil SR is a tricyclic antidepressant, an inhibitor of reuptake of norepinephrine and serotonin. Believed that the therapeutic effect of Anafranil SR is due to its ability to inhibit the reverse neuronal uptake of norepinephrine (HA) and serotonin (5-HT) released into the synaptic cleft, and the most important is the suppression of serotonin reuptake. Anafranil CP, in addition, has a wide range of other pharmacological actions: alpha1-adrenolytic, anticholinergic, antihistamine and antiserotonergic (blockade of 5-HT receptors).

Anafranil SR acts on the whole depressive syndrome, incl. especially for such typical manifestations as psychomotor retardation, depressed mood and anxiety. The clinical effect is usually observed after 2-3 weeks of treatment. Moreover, Anafranil SR has a specific (different from its antidepressant effect) effect in obsessive-compulsive disorders. The action of Anafranil SR in chronic pain syndromes, both caused and not caused by somatic diseases, is probably associated with facilitating the transmission of a nerve impulse mediated by serotonin and norepinephrine.

Indications

Adults:

– treatment of depressive conditions of various etiologies that occur with neurotic, organic, masked, involutional forms of depression depression in patients with schizophrenia and psychopathy depressive syndromes that occur in old age, due to chronic pain syndrome or chronic somatic diseases, depressive mood disorders reactive, neurotic or psychopathic nature

– obsessive-compulsive syndromes

– chronic pain syndrome

– phobias and panic attacks

– cataplexy associated with narcolepsy.

Children and adolescents:

– obsessive-compulsive syndromes

– nocturnal enuresis (only in patients over the age of 5 years and subject to the exclusion of organic causes of the disease).

Contraindications

– hypersensitivity to clomipramine and other components of the drug, cross-sensitivity to tricyclic antidepressants from the dibenzazepine group

– simultaneous use of MAO inhibitors, as well as a period of less than 14 days before and after their use

type selective use reversible action (such as moclobemide)

– recent myocardial infarction

– congenital syndrome of prolongation of the QT interval.

Do not recommend the use of the drug during pregnancy and during breastfeeding.

The drug is not recommended for use in children under the age of 5 years.

Special instructions

Tricyclic antidepressants are known to lower the seizure threshold, and therefore Anafranil CP should be used with extreme caution in patients with epilepsy. Patients who experience drowsiness and other disorders of the central nervous system (including blurred vision) while using Anafranil SR should not drive a car, operate machinery, or engage in other activities that require increased attention and quick response.

Composition of

1 tablet contains clomipramine hydrochloride 75 mg

Dosing and Administration

Doses of the drug are selected individually, taking into account the patient’s condition. The purpose of treatment is to achieve the optimal effect against the background of using the lowest possible doses of the drug, as well as to carefully increase them, especially in elderly patients and adolescents, who are generally more sensitive to Anafranil SR than patients of intermediate age groups. The initial daily dose is 75 mg (25 mg 2-3 r / day)

Side effects

Others: After a sudden cancellation or a rapid decrease in the dose of Anafranil SR, the following symptoms often occur: nausea, vomiting, abdominal pain, diarrhea, insomnia, headache, irritability, anxiety. The observed adverse events are usually mild and transient, pass during the continuation of treatment or after a decrease in the dose of Anafranil SR. They do not always correlate with the concentration of the active substance of the drug in blood plasma or with its dose. Some adverse events, such as general weakness, sleep disturbances, anxiety, anxiety, constipation, and dry mouth, are often difficult to distinguish from manifestations of depression. In case of serious side effects from the nervous system or mental status, Anafranil SR should be canceled. Elderly people are especially sensitive to the effects of Anafranil SR on the nervous system, cardiovascular system, the effect of the drug on mental status, as well as the anticholinergic effect of Anafranil SR.

Storage conditions

In a dark place at temperatures above 25 ° C.

Expiration

3 years.

Deystvuyuschee substances

clomipramine

Terms and conditions

prescription

dosage form

tablets

Indications

enuresis, neurosis navyazchyv h sostoyanyy, depression, phobia and panycheskye attacks Psyhycheskye disorders