Description
Release form
Drops.
Packaging
A bottle of yellow glass with a capacity of 10.5 ml, complete with a pipette, is placed in a cardboard box along with instructions for use.
Pharmacological action
Combined topical preparation in otolaryngology.
The therapeutic effect of Polydex is due to the anti-inflammatory effect of dexamethasone and the antibacterial effect of the antibiotics neomycin and polymyxin B. When these antibiotics are combined, the spectrum of antibacterial action on most gram-positive and gram-negative microorganisms causing infectious and inflammatory diseases of the outer and middle ear is expanded.
Neomycin is active against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae.
Polymyxin B is active against gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa.
Streptococcus spp is resistant to these antibiotics. (including Streptococcus pneumoniae).
Indications
– Otitis externa without damage to the eardrum
– infected eczema of the external auditory canal.
Contraindications
infectious or traumatic injuries of the eardrum
hypersensitivity to the components of the drug
suspected angle-closure glaucoma
concomitant use of MAO inhibitors
kidney disease accompanied by albuminuria srdlk lr.
Use during pregnancy and lactation
With prolonged treatment of pregnant women, there is a risk of an ototoxic effect on the fetus.
Special instructions
Do not administer under pressure. The simultaneous use of other aminoglycosides is not allowed. With topical use of neomycin or polymyxin B, the development of an allergic reaction may exclude the possibility of systemic use of other antibiotics that are similar in structure to neomycin and polymyxin B. When allergic to neomycin, cross-allergy with antibiotics, aminoglycosides, is possible.
Composition
Per 100 ml
Active ingredients:
Neomycin sulfate 1g, which corresponds to 650,000 ME.
Polymyxin B Sulfate 1,000,000ME.
Dexamethasone sodium metasulfobenzoate 0.100 g
Excipients: thiomersal, citric acid, 1N sodium hydroxide solution, macrogol 400, polysorbate 80, purified water qs up to 100 ml.
Dosage and administration
Adults: instill 1-5 drops in each ear 2 times a day for 6-10 days.
For children: instill 1-2 drops in each ear 2 times a day for 6-10 days. Duration of treatment – should not exceed -10 days.
Before using ear drops, it is recommended to warm the bottle by holding it in your hand, in order to avoid unpleasant sensations associated with the ingress of cold liquid into the ear. After instillation of the drug in one ear, you should tilt your head in the opposite direction for several minutes, and then instill in the other ear.
Side effects
Allergic reactions possible, rarely skin manifestations.
If the integrity of the eardrum is compromised, there is a risk of toxic effects on the auditory and vestibular apparatus.
Drug interactions
Incompatible with monomycin, streptomycin, gentamicin, amikacin, netilmicin (increased ototoxic effect).
overdose
Due to the low degree of absorption into the systemic circulation, an overdose is unlikely.
Storage conditions
At a temperature not exceeding 25 ° C out of the reach of children.
Shelf life
3 years.
Active ingredient
Dexamethasone, Neomycin, Polymyxin B
drugstore conditions
drugstore
Dosage form
drops ear
Possible product names
POLYDEX 10.5ML DROPS EARS
POLYDEX 10.5ML. EAR DROPS + PIPET
Polydex 10.5ml us.droplets
Polydex ear drops 10.5ml with
dropper POLYDEX DROPS USHN. 10,5ML
Laboratory Bouchard, France
