Description
Latin name
DICLO -F
Release form
Eye drops.
Packing
5 ml – plastic dropper bottle (1) – packs of cardboard.
Pharmacological action
Pharmacological action
NSAIDs for topical use in ophthalmology. It has anti-inflammatory, analgesic and antipyretic effects.
The mechanism of action is due to the indiscriminate inhibition of the activity of COX-1 and COX-2, which leads to the suppression of the synthesis of prostaglandins in the focus of inflammation.
When used in the form of eye drops, diclofenac sodium reduces eye inflammation resulting from infection, trauma or surgery, reduces miosis during surgery, and reduces the synthesis of prostaglandins in the moisture of the anterior chamber of the eye.
When instilling eye drops, diclofenac sodium is absorbed into the systemic circulation. However, the level of active substance in the blood is significantly lower than the detection limit and has no clinical significance.
Indications
inhibition of myosis during cataract surgery
treatment and prevention of inflammatory processes after surgery on the eyeball
prevention of cystic edema of the macula after cataract surgery
treatment of non-infectious conjunctivitis prophylactic inflammatory disease and treatment eyeball (as an adjunct to local antibiotic therapy).
Contraindications
impaired hematopoiesis of unknown genesis
erosive and ulcerative processes in the gastrointestinal tract in the acute stage
hypersensitivity to acetylsalicylic acid or other NSAIDs
hypersensitivity to diclofenac or auxiliary component.
It is used with caution in case of epithelial herpetic keratitis (including history), for diseases that cause blood coagulation disorders (including hemophilia, prolonged bleeding time, tendency to bleedings), as well as in elderly patients.
Use during pregnancy and lactation
There are currently no data on the use of the drug Diklo-F ® during pregnancy and lactation.
When using NSAIDs in the third trimester of pregnancy, an increase in the risk of fetal circulation disorders is possible.
The use of the drug in pregnant women and during breastfeeding is possible only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus or infant.
Composition
Active ingredient: diclofenac sodium – 1 ml
Excipients: benzalkonium chloride – 0.1 mg disodium edetate – 1 mg boric acid – 15 mg tromethamine – 6 mg polyoxy-35 castor oil – 20 mg povidone – 15 mg sodium hydroxide or hydrochloric acid – up to pH 7.7 water for injection – up to 1 ml.
Dosage and administration
The drug is intended for local use.
To inhibit intraoperative myosis, the drug is instilled into the conjunctival sac for 2 hours at an interval of 30 minutes (a total of 4 times) before surgery.
For the prevention of cystic edema of the macula, the drug is instilled 1 drop 3-4 times / day for 2 weeks after surgery.
For other indications – 1 drop 3-4 times / day, depending on the severity of the condition. The course of treatment can last from 1 to 2 weeks.
Side effects
From the side of the organ of vision: rarely – burning, blurred visual perception (immediately after instillation), clouding of the cornea, iritis.
Allergic reactions: itching in the eyes, hyperemia, angioedema of the face, fever, chills, photosensitivity, skin rash (mainly erythematous), urticaria, erythema multiforme.
Other: nausea, vomiting.
Drug Interaction
When co-administered with diflunisal and other NSAIDs (including acetylsalicylic acid at high doses of 3 g / day or more), sulphonylureas, methotrexate
The use of lithium, digitaloxin, and indirect anticoagulants at the same time leads to an increase in their effect.
If necessary, simultaneous administration of other medicines in the form of eye drops (including ACS), but the interval between instillations should be at least 5 minutes to prevent leaching of the active substances.
Storage conditions
The product should be stored in a dark place away from children at a temperature not exceeding 30 ° C and should not be frozen.
Shelf life
2 years. After opening the bottle, the drug should be used within 1 month.
Active ingredient o
Diclofenac
Terms and conditions
prescription
dosage form
eye drops
Possible product names
DICLO-F 0.1% 5ML GL Diklo-F 0.1% 5ml gl. Drops
Diklo-F 0.1% eye drops 5ml. X1 (R)
DIKLO-F GL. DROPS 0.1% FL. 5ML
Sentiss Farm Pvt.Ltd, India
