Description
Pharmacological action
Venotonic effect: reduces the extensibility of veins, increases venous tone, reduces venous congestion, enhances the vasoconstrictor effect of adrenaline, norepinephrine.
One tablet contains 600 mg of diosmin, which is an optimally effective daily dose for venotonic action. Angioprotective effect: improves microcirculation, increases capillary resistance, reduces their permeability. Effect on the lymphatic system: improves lymphatic drainage, increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure.
Has a decongestant effect. Reduces the symptoms of inflammation (dose-dependent effect).
Reduces the adhesion of leukocytes to the venous wall and their migration into paravasal tissues improves oxygen diffusion and perfusion in the tissue. It blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
Clinical studies have confirmed: a decrease in mean venous pressure in the superficial and deep veins of the lower extremities, demonstrated in a double-blind, placebo-controlled study conducted under the control of dopplerography, as well as an increase in systolic and diastolic blood pressure in patients with postoperative orthostatic hypotension.
Indications
Treatment of symptoms of lymphovenous insufficiency of the lower extremities (feeling of heaviness, fatigue, fullness in the legs, pain, worse by the end of the day, swelling).
Treatment of symptoms of acute hemorrhoids.
Additional treatment for microcirculatory disorders.
Contraindications
Hypersensitivity to the drug, children under 18 years of age (limited experience), not recommended during breastfeeding (limited experience).
Special instructions
Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a quick clinical effect, an additional examination and adjustment of the therapy are necessary.
In case of impaired venous circulation (varicose veins of the lower extremities, chronic lymphovenous insufficiency of the lower extremities), the maximum treatment effect is ensured by a combination of therapy with lifestyle changes: it is advisable to avoid prolonged upright stance and reduce excess body weight. In some cases, wearing special stockings (compression hosiery) helps to improve blood circulation. If there is no decrease or aggravation of the symptoms of the disease, consult a doctor!
Do not exceed the maximum dates and recommended doses of the drug without consulting your doctor!
Composition
1 film-coated tablet contains:
Composition of the tablet core:
Active ingredient: diosmin – 600.0 mg.
Excipients: microcrystalline cellulose, povidone K 30, colloidal silicon dioxide, magnesium stearate.
Composition of tablet shell 1: Opadry II pink (85F34610) (polyvinyl alcohol, titanium dioxide, macrogol 3350, talc, yellow iron dye, red iron dye, black iron dye).
Composition of the shell of tablets 2: shellac.
Dosage and administration
The drug is intended for oral administration.
Lymphatic insufficiency outside the lower extremities
In chronic lymphovenous insufficiency, 1 tablet is prescribed per day in the morning, preferably before meals. Usually the course of taking the drug is 2 months.
Acute hemorrhoids and exacerbation of chronic hemorrhoids
In acute hemorrhoids and exacerbations of chronic hemorrhoids, the drug is prescribed in the first four days, 1 tablet 3 times a day with meals, in the next three days, 1 tablet 2 times a day with meals. In case of recurrence of symptoms, the course of treatment can be repeated on the recommendation of a doctor.
Chronic hemorrhoids
After the relief of acute events, it is recommended to continue taking the drug 1 tablet 1 time per day for 1-2 months. If one or several doses of the drug is missed, it is necessary to continue the use of the drug Diosmin in the usual mode and in the usual dose.
Before using the drug, consult your doctor
Side effects
The frequency of adverse reactions is presented as follows: very often ( 1/10), often ( 1/100, <1/10), infrequently ( 1/1000. <1/100), rarely ( 1/10000, <1/1000), very rarely (<1/10000, including individual reports), the frequency is unknown (there are currently no data on the prevalence of side effects). From the gastrointestinal tract: rarely – dyspeptic disorders (heartburn, nausea, abdominal pain). From the central nervous system: rarely – headache. If any of the side effects indicated in the instructions are aggravated or you notice any other side effects not listed in the instructions, inform your doctor. Storage conditions In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children. Active ingredient Cyprus 4 year old 3 year pf686fpf686frf6 year 6fpf68 Do not use after expiration date. Active ingredient Diosmin
