Description
Release form
Chewable tablets 100 mg. On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and a printed aluminum foil varnished. 1, 2, 5 blisters with instructions for use are placed in packs of cardboard.
Pharmacological action
Ethoxidol ® is an inhibitor of free radical processes, has a membrane protective, antihypoxic, nootropic, anticonvulsant, anxiolytic effect, increases the body’s resistance to stress. Ethoxidol ® has anti-ischemic properties, improves blood flow in the ischemic zone, limits the area of ischemic damage, detects a lipid-lowering effect, reduces the content of total cholesterol and low density lipoproteins.
The drug increases the body’s resistance to various damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia,
cerebrovascular accident, intoxication with alcohol and antipsychotics (antipsychotics)).
The drug improves cerebral metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. It stabilizes the membrane structures of blood cells (red blood cells and platelets) during hemolysis.
The mechanism of action of the drug is due to its antioxidant, antihypoxic and membrane protective effect. It inhibits lipid peroxidation, increases the activity of superoxide oxidase, increases the ratio of lipid protein, reduces the viscosity of the membrane, increases its fluidity. It modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission.
Indications
– coronary heart disease (as part of complex therapy)
– complex therapy for ischemic stroke
– discirculatory encephalopathy
– mild to moderate cognitive impairment.
Contraindications
Hypersensitivity to the drug, lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
Acute hepatic and / or renal failure, pregnancy, lactation, age under 18 years (efficacy and safety have not been established).
Special instructions
During treatment, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Composition
Active ingredient: ethylmethylhydroxypyridine malate (ethoxidol) – 100 mg.
Excipients: acetylglutamic acid (N-acetyl-L-glutamic acid) – 68 mg, deanol (2-dimethylaminoethanol) – 32 mg, glycine – 20 mg, microcrystalline cellulose – 260.1 mg, povidone (collidone 90F) – 1.6 mg, lactose monohydrate (milk sugar) – 36 mg, pregelatinized starch (starch 1500) – 30 mg, colloidal silicon dioxide (aerosil) – 9.5 mg , magnesium stearate – 6 mg, croscarmellose sodium (primellose) – 12.8 mg, sodium cyclamate – 18 mg, orange flavor (flavoring food “Orange”) – 6 mg.
Dosage and administration of
100 mg (1 tablet) 3 times a day is prescribed for complex therapy of coronary heart disease and ischemic stroke therapy, gradually increasing the dose until a therapeutic effect is obtained. The maximum single dose – 200 mg daily – 800 mg. The course – at least 2 months, repeated courses – on the recommendation of a doctor.
The duration of treatment and the choice of individual dose depends on the severity of the patient’s condition and the effectiveness of the treatment.
In the complex treatment of mild and moderate cognitive impairment, the drug is prescribed without limiting the course of treatment for a duration of 100 mg 3-4 times a day.
Side effects
Typically, the drug is well tolerated. In rare cases, allergic reactions, dyspeptic disorders, nausea and dry mouth, diarrhea, which quickly disappear on their own or when the drug is discontinued, are possible. With prolonged use, flatulence, sleep disturbances (drowsiness or falling asleep) are possible.
Drug Interactions
Enhances the effects of antiepileptic drugs (carbamazepine), antiparkinsonian drugs (levodopa) and benzodiazepine anxiolytics. Increases antianginal activity of nitro drugs and antihypertensive ACE inhibitors and beta-blockers. Reduces the toxic effects of ethyl alcohol.
Overdose of
Overdose is unlikely due to the low toxicity of the drug. In case of accidental overdose, symptoms of sleep disturbance may occur – drowsiness, insomnia.
Symptomatic treatment.
Storage conditions
In a dry, dark place at a temperature of no higher than 25 ° C.
Term hodnosty
3 years
Active ingredient
Ethylmeth ilhydroxypyridine malate
terms of sale from
pharmacies Prescription
Form of Treatment
tablets dlya rassas vaniya
Appointment
Vzrosl m on purpose doctor
Indications
Prevention of heart attacks and strokes, From the consequences of a stroke, From a eroskleroza, Under the influence of adverse factors
Possible product names
Ethoxidol chewable tablets 100 mg, 50 pcs.
Synthesis AKOMP, Russia
