Description
Latin name
Quamatel
release form
coated tablets
Packing
14 pcs.
Indications
peptic ulcer of the duodenum and stomach in the exacerbation phase, prevention of relapse
treatment and prevention of symptomatic ulcers of the stomach and duodenum (associated with NSAIDs, stressful, postoperative) srd1 reflux esophagitis
Zollinger-Ellison syndrome
prevention of recurrence of bleeding from the upper gastrointestinal tract
prevention of aspiration of the gastric o juice during general anesthesia (Mendelssohn syndrome).
Contraindications
pregnancy
lactation (breastfeeding)
children
hypersensitivity to the drug
hypersensitivity to other histamine H2 receptor blockers.
Caution: the drug should be prescribed for renal and liver failure, with liver cirrhosis with a history of portosystemic encephalopathy.
Use during pregnancy and lactation
The drug is contraindicated in pregnancy.
If you need to use the drug during lactation, breastfeeding should be discontinued.
Composition
1 tablet contains:
Active ingredient:
famotidine 40 mg
Excipients:
silicon dioxide colloidal
magnesium stearate
povidone K90
sodium carboxymethyl starch (type A)
talc
corn starch
lactose monohydrate.
Dosage and administration of
In case of peptic ulcer of the stomach and duodenum in the exacerbation phase, Kvamatel is prescribed at a dose of 40 mg once a day at bedtime or 20 mg 2 times a day, morning and evening. If necessary, the daily dose can be increased to 80-160 mg. The duration of treatment is an average of 4-8 weeks.
In order to prevent exacerbations of peptic ulcer of the stomach and duodenum, Kvamatel is prescribed in a dose of 20 mg once a day at bedtime.
With reflux esophagitis, the drug is prescribed in a dose of 20 mg 2 times a day (morning and evening) for 6 weeks, if necessary – 40 mg 2 times a day.
With Zollinger-Ellison syndrome, the initial dose is 20-40 mg every 6 hours, if necessary, the daily dose can be increased to 240-480 mg. The duration of use of the drug depends on the clinical condition of the patient.
In order to prevent aspiration of gastric contents during general anesthesia, Kvamatel is prescribed in a dose of 40 mg on the eve of surgery and / or in the morning on the day of surgery.
Side effects of the digestive system: dry mouth, nausea, vomiting, abdominal pain, flatulence, constipation, diarrhea, decreased appetite, increased liver transaminase activity, hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis.
From the hemopoietic system: very rarely – agranulocytosis, pancytopenia, leukopenia, thrombocytopenia, hypo- or aplasia of the bone marrow.
Allergic reactions: urticaria, skin rash, itching, bronchospasm, angioedema, anaphylactic shock.
From the cardiovascular system: arrhythmia, bradycardia, AV block, decreased blood pressure.
From the side of the central nervous system: headache, dizziness, drowsiness, hallucinations, confusion, increased fatigue, depression, agitation, anxiety.
From the sensory organs: decreased visual acuity, tinnitus.
From the reproductive system: with prolonged use in high doses – hyperprolactinemia, gynecomastia, amenorrhea, decreased libido.
From the musculoskeletal system: arthralgia, muscle cramps.
Dermatological reactions: alopecia, acne vulgaris, dry skin, toxic epidermal necrolysis.
Other: fever.
Drug Interaction
Due to the increase in the pH of the contents of the stomach, Kwamatel with simultaneous application reduces the absorption of ketoconazole and itraconazole increases the absorption of amoxicillin and clavulanic acid.
Antacids and sucralfate co-administered with Kvamatel slow the absorption of famotidine.
The simultaneous intake of Kvamatel and bone marrow suppressants increases the risk of neutropenia.
Overdose
Symptoms: vomiting, motor excitation, tremor, decreased blood pressure, tachycardia, collapse.
Treatment: gastric lavage, symptomatic and supportive hemodialysis therapy.
Storage conditions
In the dark place at a temperature of 25 ° C.
Expiration
5 years.
pharmacy terms and conditions for prescription
dosage form
dosage form
tablets
Gedeon Richter Vengriya
