Description
Release form srdlp tablets.
Packing
20 pcs.
Pharmacological action of
Antimicrobial, antibacterial (bacteriostatic). Derivative of nitrofuran.
Furazolidone disrupts the activity of certain bacterial enzyme systems.
Active against gram-negative microorganisms (Shigella spp., Salmonella spp.,) and some gram-positive microorganisms, Trichomonas, Giardia. Inactive against pathogens of purulent and anaerobic infections. Furazolidone is also active against a number of bacteria that are resistant to antibiotics and sulfonamides. The resistance of microorganisms to furazolidone develops slowly.
Quickly absorbed in the digestive tract, distributed throughout the tissues (including the central nervous system), in the liver turns into an amino derivative. Excreted by the kidneys and intestines.
Contraindications
The terminal stage of chronic renal failure, impaired liver function, glucose-6-phosphate dehydrogenase deficiency, pregnancy, lactation, children under 8 years of age, increased individual sensitivity to drug components and nitrofurans.
Do not prescribe for urinary tract infections.
Special instructions
Limited for use in chronic renal failure, diseases of the nervous system. For the prevention of neuritis with prolonged use, it is necessary to combine with B vitamins.
Furozolidone has the ability to sensitize the body to the action of alcohol and can be used to treat chronic alcoholism with insufficient effectiveness of other drugs or the presence of contraindications for their use.
It should be borne in mind that Furazolidone is an MAO inhibitor, therefore, when using it, the same precautions should be followed as when using classic MAO inhibitors.
Composition
1 tablet contains:
active ingredient: furazolidone – 50 mg
excipients: lactose monohydrate, anhydrous colloidal silicon dioxide, calcium stearate, potato starch.
Dosage and administration
The drug is taken orally after a meal with a large amount of liquid (100-200 ml).
For dysentery, paratyphoid, food toxicoinfections for adults are prescribed 2-3 tablets (100-150 mg) 4 times a day (but not more than 800 mg) for 5-10 days. Children over 8 years of age are prescribed a drug at a rate of 6-7 mg / kg body weight per day, the daily dose is divided into 4 doses. The duration of the course depends on the severity of the disease and the effectiveness and sensitivity to therapy.
In case of giardiasis, adults are prescribed 2 tg 6 ^ ¸ò ê Ù Ù Ç Ù – – 1 ^?? ^ – – ducks for children over 8 years old are prescribed the drug at a rate of 6 mg / kg body weight per day in 3-4 doses. The course of treatment is 5-10 days.
The therapeutic effect in the treatment of diarrhea with furazolidone develops within 2-5 days of therapy. Sometimes patients may require a longer treatment period. If a satisfactory clinical response is not received within 7 days, this means that the pathogen is refractory to the action of furazolidonone and the drug should be discontinued. It is possible to prescribe additional therapy with other antibacterial agents or bismuth salts.
Highest doses for adults: single – 200 mg, daily – 800 mg. It is not recommended to take furazolidone for more than 10 days.
Side effects
In some cases, nausea, vomiting, loss of appetite, allergic reactions (skin rash, hyperemia and itching of the skin, allergic edema) can occur.
Drug Interactions
Urine alkalizing agents reduce the effect (accelerate urine excretion), acidifying agents increase it. Aminoglycosides and tetracycline enhance antimicrobial properties.
Increases inhibition of hematopoiesis against the background of chloramphenicol and ristomycin.
Overdose
Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).
Treatment: drug withdrawal, large fluid intake, symptomatic therapy, antihistamines, and B vitamins.
Storage Conditions
In a dry, dark place.
Deystvuyuschee substances
furazolidone
Form of Treatment tablets
Borisov water, Belarus
