Description
release form
tablets
Packing
30 pcs
Pharmacological action of
Detralex ® has venotonic and angioprotective properties.
The drug reduces the extensibility of veins and venous congestion, reduces the permeability of capillaries and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug in relation to venous hemodynamics.
The statistically significant dose-dependent effect of Detralex ® was demonstrated for the following venous plethysmographic parameters: venous capacity, venous extensibility, time of venous emptying. The optimal dose / effect ratio is observed when taking 2 tablets.
Detralex ® improves venous tone: venous occlusion plethysmography has been shown to decrease venous emptying time. In patients with signs of severe microcirculatory disturbance, (statistically significant) is observed, compared with placebo, increased capillary resistance, evaluated by angiostereometry, after treatment with Detralex ®.
The therapeutic efficacy of Detralex ® has been proven in the treatment of chronic lower extremity vein diseases, as well as in the treatment of hemorrhoids.
Pharmacokinetics
The main excretion of the drug occurs with feces. With urine, on average, about 14% of the accepted amount of the drug is excreted.
T1 / 2 is 11 hours.
The drug undergoes active metabolism, as evidenced by the presence of phenolic acids in the urine.
Indications
Symptomatic therapy of venous-lymphatic insufficiency, feeling of heaviness in the legs, pain, Morning leg fatigue, cramps, trophic disorders, symptomatic therapy of exacerbation of hemorrhoids.
Contraindications
Hypersensitivity to the components of the drug.
Pregnancy and lactation
Pregnancy
Animal experiments have not revealed teratogenic effects.
To date, there have been no reports of any side effects when using the drug in pregnant women.
Breastfeeding
Due to a lack of data regarding the excretion of the drug in breast milk, lactation is not recommended for women.
Dosage and administration
The drug is taken orally.
The recommended dose is 2 tablets per day, 1 tablet in the middle of the day and 1 tablet in the evening with meals.
During an exacerbation of hemorrhoids – 6 tablets per day for 4 days, then 4 tablets per day for the next 3 days.
Side effects of
From the central nervous system: rarely – dizziness, headache, general malaise.
From the gastrointestinal tract: often – diarrhea, dyspepsia, nausea, vomiting infrequently – colitis.
From the skin: rarely – rash, itching, urticaria of unspecified frequency – isolated swelling of the face, lips, eyelids. In exceptional cases, angioedema.
Storage conditions
The product should be stored out of the reach of children at a temperature not exceeding 30 ° C.
Term hodnosty
4 years
Active ingredient
Hesperidin, Diosmin
lekarstvennaja form
tablets
For prescribed
Adults as prescribed by the doctor, Pregnant as prescribed by the doctor
Indications
Indications
Hemorrhoids, trophic ulcers, varicose veins
Servier / Serdiks, Russia
