Description
Release form
Infusion solution.
Packing
Bottle 100 ml.
Pharmacological action
Uman albumin is a plasma replacement drug obtained by fractionating blood and plasma from healthy donors. Albumin is a protein with a molecular weight of 69,000 daltons, which is an integral part of the protein fraction of human blood.
Replenishes a deficiency of plasma albumin, maintains colloid osmotic (oncotic) blood pressure, quickly increases blood pressure and overall BCC, promotes the transition of fluid from tissue to the bloodstream, and has detoxification properties.
Indications
Replacement therapy for severe albumin deficiency
Contraindications
All conditions in which hypervolemia or its consequences (increased stroke volume, high blood pressure) or hemodilution may pose a risk to the patient: decompensated heart failure
arterial hypertension
varicose veins of the esophagus
renal and postrenal anuria
dehydration (if fluid replenishment is not performed simultaneously).
increased individual sensitivity to the components of the drug.
Caution: the drug should be prescribed for renal failure, thrombosis, ongoing internal bleeding, chronic heart failure.
Use during pregnancy and lactation
Uman Albumin should be used during pregnancy and during breastfeeding only if the potential benefit to the mother outweighs the potential risk to the fetus or baby.
Composition
Active ingredient: human albumin 200 mg
Dosage and administration
The dosage regimen and rate of administration of the drug are calculated based on the individual patient metrics.
The minimum colloidal osmotic pressure is 20 mmHg. Art. (2.7 kPa).
When prescribing human albumin, the required dose in grams can be calculated using the following formula:
[required total protein (g / l) – available total protein (g / l)]? plasma volume (l)? 2.
The physiological plasma volume can be calculated as corresponding to 40 ml / kg body weight.
As this formula is approximate in some cases, laboratory monitoring of protein concentration is recommended. In the case of extensive substitution therapy and with a decrease in hematocrit below 30%, a red blood cell transfusion is necessary to maintain oxygen transport by blood.
The drug is administered only intravenously.
The rate of infusion is determined in accordance with individual characteristics and indications, as a rule, for 20% and 25% solutions – 1-2 ml / min. The maximum administration time is 3 hours. During plasmapheresis, the infusion rate should not exceed 30 ml / min.
With the introduction of large volumes, Before use, the drug should be warmed to room temperature or to body temperature.
Drug Interactions
So far, no human albumin interactions with other drugs have been reported.
The drug should not be mixed with other drugs, blood or red blood cells, as this may lead to precipitation of the protein.
Overdose
With frequent administration of the drug at high doses, hypervolemia may develop.
At the first clinical manifestations of heart failure (headache, suffocation), increased blood pressure, increased central venous pressure, pulmonary edema, the infusion should be stopped immediately, and the patient’s blood count (hemoglobin, hematocrit) should be clearly monitored.
It is suggested that diuresis and cardiac output may increase depending on the severity of the clinical picture.
Storage Conditions
The product should be stored in a dark place out of the reach of children at a temperature not exceeding 30 ° C. Do not freeze.
Shelf life
3 years.
Deystvuyushtee substance
Alybumin per person
Dosage form
solution for infusion
Prescription
Prescription
For adults prescribed by a doctor For children prescribed by a doctor
