indapamide – is released Indapamide tablets 2.5 mg 30 pcs

$14.00

SKU: USUK8837l5 Category:

Description

Release form srdl kp Tablets, film-coated white, round, biconvex, without risks in the transverse section – white or almost white.

Pharmacological action

Thiazide-like diuretic, antihypertensive agent. It causes a decrease in the tone of smooth muscles of the arteries, a decrease in OPSS, also has moderate saluretic activity, due to impaired reabsorption of sodium, chlorine and water ions in the cortical segment of the Henle loop and the proximal convoluted tubule of the nephron. The decrease in OPSS is due to several mechanisms: a decrease in the sensitivity of the vascular wall to norepinephrine and angiotensin II by an increase in the synthesis of prostaglandins, which have vasodilating activity by inhibiting the influx of calcium ions into the smooth muscle elements of the vascular wall. In therapeutic doses, virtually no effect on lipid and carbohydrate metabolism. The antihypertensive effect is manifested only with initially elevated blood pressure, develops by the end of the first week and reaches a maximum after 3 months of systematic administration.

Indications

Arterial hypertension.

Contraindications

Hypersensitivity to indapamide and other components of the drug, as well as to other sulfonamide derivatives, severe renal failure (creatinine clearance less than 30 ml / mia), hypokalemia, hepatic encephalopathy or severe impairment of liver function, acute brain impairment, acute brain impairment, lactation, up to 18 years of age (efficacy and safety not established) lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome (the drug contains l ktozu). With caution: in case of impaired liver and / or kidney function, disturbances in the water-electrolyte balance, hyperparathyroidism, in debilitated patients or in patients receiving combination therapy with other antiarrhythmic drugs, while taking drugs that extend the QT interval, diabetes mellitus, hyperuricemia (especially accompanied by gout and urate nephrolithiasis). Use during pregnancy and during breastfeeding. But during pregnancy, diuretic drugs should not be prescribed. You can not use these drugs to treat physiological edema during pregnancy. Diuretic drugs can cause fetoplacental and lemu and lead to impaired fetal development (hypotrophy). The use of the drug INDAPAMID is not recommended during pregnancy. Indapamide is excreted in breast milk. Given the possibility of adverse events in infants, breast-feeding during treatment with INDAPAMID is not recommended.

Composition

1 tab. indapamide 2.5 mg.

Excipients: lactose monohydrate – 72 mg, microcrystalline cellulose – 10 mg, corn starch – 10.1 mg, magnesium stearate – 0.9 mg, polyvinylpyrrolidone – 3.6 mg, talc – 0.9 mg.

Shell composition: hypromellose – 1.873 mg, polysorbate 80 – 0.828 mg, titanium dioxide – 0.728 mg, castor oil – 0.23 mg, talc – 0.728 mg, macrogol 4000 – 0.613 mg.

Dosage and administration of

Tablets are taken orally without chewing. The daily dose is 1 tablet of the drug INDAPAMID 1 time per day (in the morning), washed down with a sufficient amount of liquid.

In the treatment of patients with arterial hypertension, the dose should not exceed 2.5 mg (increased risk of side effects without enhancing the antihypertensive effect).

Elderly patients. In elderly patients, the plasma concentration of creatinine should be monitored taking into account age, body weight and gender.

Indapamide at a dose of 2, 5 mg / day (1 tablet) can be prescribed for elderly patients with normal or slightly impaired renal function ..

Severe renal failure: The drug is contraindicated

Overdose

Symptoms. Signs of acute drug poisoning are primarily associated with a violation of the water-electrolyte balance (hyponatremia, hypokalemia). Of the clinical symptoms of an overdose, nausea, vomiting, impaired gastrointestinal function, cramps, dizziness, drowsiness, confusion, polyuria or oliguria, leading to anuria (due to hypovolemia), may occur in some cases, an excessive decrease in blood pressure, respiratory depression. In patients with cirrhosis, the development of hepatic coma is possible.

treatment. Emergency measures are reduced to removing the drug from the body: washing the stomach and / or prescribing activated carbon, followed by restoration of the water-electrolyte balance. There is no specific antidote.

Storage conditions

Store in a dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Expiration

3 years. Do not use after the expiration date indicated on the package.

Deystvuyuschee substances

indapamide

Terms and conditions

prescription

Dosage form

tablets