Description
Release form
Sustained-release tablets.
Packing
20 pcs.
Pharmacological action
Peripheral vasodilator with a primary effect on venous vessels. Cardiket has an antianginal and hypotensive effect.
The mechanism of action is associated with dilatation of blood vessels (mainly post-capillary) and large arteries. Dilation of the vessels of the postcapillary bed leads to venous deposition of blood and a decrease in venous return of blood to the heart. As a result of a decrease in left ventricular filling (a decrease in preload), myocardial oxygen demand decreases, which helps to increase capillary blood flow, open the lumen of previously non-functioning intramural coronary vessels, and also improve oxygen supply to the ischemic subendocardial region.
Dilatation of precapillary vessels leads to a decrease in systolic pressure in the aorta and OPSS (decrease in afterload). As a result, the cardiac output of the left ventricle and the myocardial oxygen demand are reduced.
Direct dilatation of the coronary vessels and a slight decrease in the resistance of the coronary vessels improve myocardial perfusion and oxygen supply without the development of a robbery syndrome.
Indications
prevention of angina attacks
rehabilitation treatment after myocardial infarction
pulmonary hypertension
chronic heart failure (as part of combination therapy).
Contraindications
acute myocardial infarction
acute circulatory failure (shock, vascular collapse)
severe arterial hypotension (systolic blood pressure less than 90 mm Hg).
Use during pregnancy and lactation
The use of the drug Cardiket during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.
If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.
Special instructions
Cardicet retard should not be prescribed to relieve an attack of angina pectoris.
A severe headache that occurs at the beginning of therapy, in most cases, significantly decreases or completely disappears with continued administration of the drug.
Alcohol should be avoided during treatment with Cardicet.
Influence on the ability to drive vehicles and control mechanisms
The question of the possibility of engaging in potentially hazardous activities should be decided only after assessing the patient’s individual reaction to the drug.
Ingredients
1 tablet contains:
Active ingredient: isosorbide dinitrate 40 mg
Excipients: lactose monohydrate talc magnesium stearate polyvinyl acetate starch potato starch
Dosage and administration
The dose is selected individually, because it depends on the stage of the disease and the individual need for nitrates. Tablets are prescribed 1 tab. 2-3 times / day, Cardiket should be taken after a meal, without chewing and drinking with a small amount of liquid. When prescribing more than 1 tablet / day, the interval between doses should be at least 8 hours (to ensure the full effect of the drug).
Side effects
From the cardiovascular system: at the beginning of treatment – severe headache (due to dilation of the venous channel of the brain vessels) possibly – tachycardia, orthostatic hypotension.
From the side of the central nervous system: drowsiness.
From the gastrointestinal tract: in some cases – nausea, vomiting.
Dermatological reactions: in some cases, erythematous rashes.
Drug interaction
With the simultaneous use of Cardicet retard with antihypertensive drugs, cyclic antidepressants, MAO inhibitors, it is possible to increase its hypotensive effect.
With the simultaneous use of Cardicet retard, the action of dihydroergotamine and ethanol is potentiated.
Overdose
Symptoms: headache, palpitations, dizziness, hypotension, nausea, vomiting.
Treatment: symptomatic.
Storage Conditions
The product should be stored at a temperature not exceeding 25 ° C.
Dosage form
tablet prolong.
Indications
angina, chronic circulatory insufficiency, prevention of acute myocardial infarction
Possible product names
CARDET 0.04 N20 TABLES PROLONG
CARD 40 N20 TABLES PROLONG
Card 40 mg Tab. prol. valid X20 (R) $
Cardiket 40mg Tab. prolong. valid X20 (R)
Cardiket 40mg No. 20
ASIC Pharmaceuticals GmbH, Belgium
