Description
Form
release Capsules
Packing
6 pcs
Indications
dermatomycosis and dermatophytosis, including severe lesions of the hands, feet, onychomycosis caused by dermatophytes and / or yeast, mold and dimorphic g
fungi candidiasis (fungal infections with skin and mucous membranes): lichen versicolor, inguinal epidermophytosis, oral and visceral (internal organs) candidiasis, pulmonary candidiasis, vulvovaginal candidiasis, fungal keratitis
deep mycoses: blastomycosis, coccidiomycosis, paracoccidiomycosis, sporotrichosis, foot mycetoma, histoplasmosis, chromomycosis, penicillosis
systemic mycoses: systemic aspergillosis and candidiasis of various localization, cryptococcosis (including cryptococcal meningitis), histoplasmosis, paracoccicosis or sporcidiasis or sporcidiasis or sporcidiasis or sporcidiasis or sporcidiasis or sporcidiasis or sporcidiasis or sporcidiasis or sporcidiasis or sporcidiasis, sporoticosis, or sporcociosis, or sporcidiasis or sporcidiasis or sporcidiasis or sporcidiasis
Contraindications drug susceptibility to pregnancy, Ip.
Use during pregnancy and lactation
Women of childbearing age, taking Irunin, it is necessary to use adequate methods of contraception throughout the course of treatment until the onset of the first menstruation after its completion.
Pregnant women in the II and III trimester Irunin should be prescribed only if the expected benefit to the woman outweighs the potential risk to the fetus.
Since a small amount of itraconazole is excreted in breast milk, the expected benefits of taking itraconazole must be weighed against the risk to the baby during breastfeeding.
In case of doubt, the issue of terminating breastfeeding should be resolved.
Composition
1 capsule contains:
Active ingredient:
itraconazole
Excipients:
sucrose,
starch,
hydroxypropyl methylcellulose,
poloxamer.
Dosage and administration
The drug Irunin is prescribed inside immediately after a meal, the capsules are swallowed whole.
With vaginal candidiasis, the drug is prescribed at a dose of 200 mg 2 times a day for 1 day or at a dose of 200 mg 1 time per day for 3 days.
With fungal skin diseases – 100 mg once a day for 15 days.
With candidiasis of the oral cavity – 100 mg 1 time per day for 15 days.
For fungal diseases of the nails, Irunin is prescribed at a dose of 200 mg / day for 3 months or repeat courses of 200 mg 2 times a day for 1 week with subsequent interruptions (pulse therapy).
In case of fungal diseases of internal organs – 200 mg once a day for 2-7 months, if necessary, increase the dose of Irunin to 200 mg 2 times a day.
Side effects
Rarely – itching, burning sensation in the vagina, skin rash in the genital area that does not require withdrawal the drug.
Drug interaction
Strengthens and lengthens the effect of drugs metabolized by enzymes such as cytochrome P450 (isoenzyme CYP3A4): terfenadine, astemizole, cisapride midazolam, triazolam, indirect medication, medication, medication such as dihydropyridine, quinidine, tacrolimus and vincristine.
CYP3A4 isoenzyme inhibitors (ritonavir, indinavir, clarithromycin) increase bioavailability.
Inductors of microsomal oxidation in the liver (rifampicin, isoniazid, phenytoin) reduce bioavailability.
Antacid drugs, m-anticholinergics, H2-histamine receptor blockers, omeprazole and sucralfate reduce absorption (the interval between doses should be at least 2 hours). When combined with cisapride, the toxicity of the latter increases with the development of ventricular arrhythmia.
Storage Conditions
In a dry, dark place at a temperature not exceeding 25 ° C.
Expiration
2 years
Active ingredient
Itraconazole
Terms leave Pharmacies
Prescription
lekarstvennaja
capsule
Indications
Indications
from yeast
