Description
Latin name
Livarol
Release form
Livarol ® vaginal suppositories 400 mg. 5 suppositories are placed in blister strip packaging. One or two blister packs along with instructions for medical use of the drug are placed in a pack of cardboard.
Packing
10 pcs
Pharmacological action
The active substance is ketoconazole, a derivative of imidazole dioxolane. It has fungicidal and fungistatic effects against dermatophytes (Trichophyton spp., Epidermophyton floccosum, Microsporum spp.) And yeast (Candida spp., Pityrosporum spp.). The mechanism of action is the inhibition of ergosterol biosynthesis and a change in the lipid composition of the fungal membrane.
The drug is active against staphylococci and streptococci.
Pharmacokinetics
Systemic absorption with intravaginal administration is negligible.
Indications
Treatment of acute and chronic recurrent vaginal candidiasis.
Prevention of the occurrence of fungal infections of the vagina with reduced resistance of the body and during treatment with antibacterial agents and other drugs that violate the normal microflora of the vagina.
Special instructions
In rare cases, allergic reactions (hyperemia of the penis) in the sexual partner are possible.
Simultaneous treatment of the sexual partner is recommended to reduce the risk of relapse.
Composition
One vaginal suppository contains: Active ingredient: ketoconazole – 400 mg
Excipients: butylhydroxyanisole – 0.5 mg
suppository base: macrogol-1500 (92 – 98)%, macrogol-400 (8 – 2)% – to obtain a suppository weighing 3.0 g.
Dosage and administration
Having previously released the suppository from contour packaging, inject it deep into the vagina in the supine position, 1 suppository per day for 3-5 days, depending on the course of the disease. In chronic candidiasis, 1 suppository is used for 10 days.
Side effects
Hyperemia and mucus irritationstagnant sheath of the vagina, itching of the vagina. Allergic reactions: skin rash, urticaria.
Drug Interactions
When using Livarol ® Vaginal Suppositories 400 mg, negative interactions with other drugs are not known and should not be expected, since the resorption capacity of ketoconazole is low.
Storage conditions
Keep out of the reach and sight of children, in a dry, dark place at a temperature not exceeding 25 ° C.
Expiration
2 years.
active substance
ketoconazole
Terms leave around drugstore
Without a prescription
lekarstvennaja form
suppozytoryy vahynaln e
Nizhpharm, Russia
