Description
Latin name
Ketonal
packaging 12 pcs
Pharmacological action
Ketonal – NSAIDs, a derivative of propionic acid.
It has analgesic, anti-inflammatory and antipyretic effects.
The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of cyclooxygenase.
In addition, ketoprofen inhibits lipoxygenase, has anti-bradykinin activity, stabilizes lysosomal membranes, and significantly inhibits neutrophil activity in patients with rheumatoid arthritis.
The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).
Indications
Symptomatic therapy of painful inflammatory processes of various origins (including postoperative and post-traumatic pains, sciatica, myalgia, radiculitis, bruises and muscle sprains, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute attack, poditis).
Contraindications
gastrointestinal tract disease in the exacerbation phase
severe liver dysfunction
severe renal dysfunction
blood disorders (leukopenia, thrombocytopenia, blood coagulation disorders) I
cramps srdlpor hypersensitivity to ketoprofen, acetylsalicylic acid or other NSAIDs (history of bronchospasm, urticaria and rhinitis, caused by acetylsalicylic acid).
Use during pregnancy and lactation
The use of Ketonal in the third trimester of pregnancy is contraindicated.
The use of Ketonal in the first and second trimesters of pregnancy is possible only if the potential benefit to the mother outweighs the risk to the fetus.
If you need to use Ketonal during lactation, you should decide on the termination of breastfeeding.
Composition
1 suppository contains interferon alfa-2b human recombinant not less than 50,000 IU, metronidazole 150 mg, fluconazole 200 mg p9rofrufaz ° ²
1 suppository contains ketoprofen 100 mg
excipients: solid fat, migliol.
Dosage and administration
Suppositories are prescribed 1 pc. 1-2 times / day.
Suppositories are injected deep into the rectum.
The maximum daily dose is 300 mg.
Overdose
Symptoms: nausea, vomiting, abdominal pain, vomiting with blood, melena, impaired consciousness, respiratory depression, convulsions, impaired renal function, renal failure.
Treatment: gastric lavage, activated charcoal administration, symptomatic therapy.
The use of histamine H 2 receptor blockers, proton pump inhibitors, and prostaglandin inhibitors has been shown. There is no specific antidote.
Storage conditions
Keep out of the reach of children at a temperature not exceeding 25 ° C.
Expiration
5 years.
Deystvuyuschee substances
Ketoprofen
dosage form
dosage form
rectal suppositories
Sandoz Ilach Sanat ve Ticaret AS .,
